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10.1016/j.jcis.2020.12.021 http://scihub22266oqcxt.onion/10.1016/j.jcis.2020.12.021 33652169!9749415!33652169     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Colloid+Interface+Sci 2021 ; 592 (ä): 156-166 Nephropedia Template TP {{tp|p=33652169|t=2021. Multidomain drug delivery systems of beta-casein micelles for the local oral co-administration of antiretroviral combinations |pdf=|usr=}}{{33652169}} gab.com Text Multidomain drug delivery systems of beta-casein micelles for the local oral co-administration of antiretroviral combinations JO: J Colloid Interface Sci http://www.kidney.de/pget.php?&tw=1&pmid=33652169 #FOAvip The antiretroviral (ARV) cocktailrevolved the treatment of the human immunodeficiency virus (HIV) infection. Drug combinations have been also tested to treat other infectious diseases, including the recentcoronavirus disease 2019 (COVID-19) outbreak. To simplify administration fixed-dose combinationshave been introduced, however, oral anti-HIV therapy still struggles with low oral bioavailability of many ARVs.This work investigated the co-encapsulation of two clinically relevant ARV combinations,tipranavir (TPV):efavirenz (EFV) anddarunavir (DRV):efavirenz (EFV):ritonavir (RTV),within the core of beta-casein (bCN) micelles. Encapsulation efficiency in both systems was ~100%. Cryo-transmission electron microscopy and dynamic light scattering of the ARV-loaded colloidaldispersions indicatefull preservation of the spherical morphology, and x-ray diffraction confirm that the encapsulated drugs are amorphous. To prolong the physicochemical stabilitythe formulations were freeze-driedwithout cryo/lyoprotectant, and successfully redispersed, with minor changes in morphology.Then, theARV-loaded micelles were encapsulated within microparticles of Eudragit(R) L100, which prevented enzymatic degradation and minimized drug release under gastric-like pH conditionsin vitro. At intestinal pH, the coating polymer dissolved and released the nanocarriers and content. Overall, our results confirm the promise of this flexible and modular technology platform for oral delivery of fixed dose combinations. Twit Text FOAVip Multidomain drug delivery systems of beta-casein micelles for the local oral co-administration of antiretroviral combinations ????J Colloid Interface Sci http://www.kidney.de/pget.php?&tw=1&pmid=33652169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33652169 #FOAvip English Wikipedia <ref>{{Cite pmid|33652169}}</ref> Multidomain drug delivery systems of beta-casein micelles for the local oral co-administration of antiretroviral combinations #MMPMID33652169 Singh Chauhan P; Abutbul Ionita I; Moshe Halamish H; Sosnik A; Danino D J Colloid Interface Sci 2021[Jun]; 592 (ä): 156-166 PMID33652169show ga The antiretroviral (ARV) cocktailrevolved the treatment of the human immunodeficiency virus (HIV) infection. Drug combinations have been also tested to treat other infectious diseases, including the recentcoronavirus disease 2019 (COVID-19) outbreak. To simplify administration fixed-dose combinationshave been introduced, however, oral anti-HIV therapy still struggles with low oral bioavailability of many ARVs.This work investigated the co-encapsulation of two clinically relevant ARV combinations,tipranavir (TPV):efavirenz (EFV) anddarunavir (DRV):efavirenz (EFV):ritonavir (RTV),within the core of beta-casein (bCN) micelles. Encapsulation efficiency in both systems was ~100%. Cryo-transmission electron microscopy and dynamic light scattering of the ARV-loaded colloidaldispersions indicatefull preservation of the spherical morphology, and x-ray diffraction confirm that the encapsulated drugs are amorphous. To prolong the physicochemical stabilitythe formulations were freeze-driedwithout cryo/lyoprotectant, and successfully redispersed, with minor changes in morphology.Then, theARV-loaded micelles were encapsulated within microparticles of Eudragit(R) L100, which prevented enzymatic degradation and minimized drug release under gastric-like pH conditionsin vitro. At intestinal pH, the coating polymer dissolved and released the nanocarriers and content. Overall, our results confirm the promise of this flexible and modular technology platform for oral delivery of fixed dose combinations. |*Anti-Retroviral Agents/chemistry/pharmacokinetics/pharmacology[MESH] |*COVID-19 Drug Treatment[MESH] |*Caseins/chemistry/pharmacokinetics/pharmacology[MESH] |*HIV-1[MESH] |*Micelles[MESH] |*SARS-CoV-2[MESH] |Delayed-Action Preparations/chemistry/pharmacokinetics[MESH] |Drug Combinations[MESH] |HIV Infections/*drug therapy[MESH]Multidomain drug delivery systems of beta-casein micelles for the loca(epmc).pdf DeepDyve Pubget Overpricing