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10.7554/eLife.67569 http://scihub22266oqcxt.onion/10.7554/eLife.67569 33650967!7987337!33650967     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=33650967|t=2021. Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study |pdf=|usr=}}{{33650967}} gab.com Text Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33650967 #FOAvip BACKGROUND: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. METHODS: This is a nested case-control study in which we compared male participants with extreme phenotype selected from the Italian GEN-COVID cohort of SARS-CoV-2-infected participants (<60 y, 79 severe cases versus 77 control cases). We applied the LASSO Logistic Regression analysis, considering only rare variants on young male subsets with extreme phenotype, picking up TLR7 as the most important susceptibility gene. RESULTS: Overall, we found TLR7 deleterious variants in 2.1% of severely affected males and in none of the asymptomatic participants. The functional gene expression profile analysis demonstrated a reduction in TLR7-related gene expression in patients compared with controls demonstrating an impairment in type I and II IFN responses. CONCLUSIONS: Young males with TLR7 loss-of-function variants and severe COVID-19 represent a subset of male patients contributing to disease susceptibility in up to 2% of severe COVID-19. FUNDING: Funded by private donors for the Host Genetics Research Project, the Intesa San Paolo for 2020 charity fund, and the Host Genetics Initiative. CLINICAL TRIAL NUMBER: NCT04549831. Twit Text FOAVip Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33650967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33650967 #FOAvip English Wikipedia <ref>{{Cite pmid|33650967}}</ref> Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study #MMPMID33650967 Fallerini C; Daga S; Mantovani S; Benetti E; Picchiotti N; Francisci D; Paciosi F; Schiaroli E; Baldassarri M; Fava F; Palmieri M; Ludovisi S; Castelli F; Quiros-Roldan E; Vaghi M; Rusconi S; Siano M; Bandini M; Spiga O; Capitani K; Furini S; Mari F; Renieri A; Mondelli MU; Frullanti E Elife 2021[Mar]; 10 (ä): ä PMID33650967show ga BACKGROUND: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. METHODS: This is a nested case-control study in which we compared male participants with extreme phenotype selected from the Italian GEN-COVID cohort of SARS-CoV-2-infected participants (<60 y, 79 severe cases versus 77 control cases). We applied the LASSO Logistic Regression analysis, considering only rare variants on young male subsets with extreme phenotype, picking up TLR7 as the most important susceptibility gene. RESULTS: Overall, we found TLR7 deleterious variants in 2.1% of severely affected males and in none of the asymptomatic participants. The functional gene expression profile analysis demonstrated a reduction in TLR7-related gene expression in patients compared with controls demonstrating an impairment in type I and II IFN responses. CONCLUSIONS: Young males with TLR7 loss-of-function variants and severe COVID-19 represent a subset of male patients contributing to disease susceptibility in up to 2% of severe COVID-19. FUNDING: Funded by private donors for the Host Genetics Research Project, the Intesa San Paolo for 2020 charity fund, and the Host Genetics Initiative. CLINICAL TRIAL NUMBER: NCT04549831. |*Polymorphism, Single Nucleotide[MESH] |Adult[MESH] |COVID-19/diagnosis/epidemiology/*genetics[MESH] |Case-Control Studies[MESH] |Genetic Predisposition to Disease[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/isolation & purification[MESH] |Severity of Illness Index[MESH]Association of Toll-like receptor 7 variants with life-threatening COV(epmc).pdf DeepDyve Pubget Overpricing