Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/ijmm.2021.4897 http://scihub22266oqcxt.onion/10.3892/ijmm.2021.4897 33649798!7914073!33649798     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2021 ; 47 (4): ä Nephropedia Template TP {{tp|p=33649798|t=2021. COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease |pdf=|usr=}}{{33649798}} gab.com Text COVID 19 and SARS CoV 2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33649798 #FOAvip Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2), the causative viral agent for the ongoing COVID?19 pandemic, enters its host cells primarily via the binding of the SARS?CoV?2 spike (S) proteins to the angiotensin?converting enzyme 2 (ACE2). A number of other cell entry mediators have also been identified, including neuropilin?1 (NRP1) and transmembrane protease serine 2 (TMPRSS2). More recently, it has been demonstrated that transmembrane protease serine 4 (TMPRSS4) along with TMPRSS2 activate the SARS?CoV?2 S proteins, and enhance the viral infection of human small intestinal enterocytes. To date, a systematic analysis of TMPRSS4 in health and disease is lacking. In the present study, using in silico tools, the gene expression and genetic alteration of TMPRSS4 were analysed across numerous tumours and compared to controls. The observations were also expanded to the level of the central nervous system (CNS). The findings revealed that TMPRSS4 was overexpressed in 11 types of cancer, including lung adenocarcinoma, lung squamous cell carcinoma, cervical squamous cell carcinoma, thyroid carcinoma, ovarian cancer, cancer of the rectum, pancreatic cancer, colon and stomach adenocarcinoma, uterine carcinosarcoma and uterine corpus endometrial carcinoma, whilst it was significantly downregulated in kidney carcinomas, acute myeloid leukaemia, skin cutaneous melanoma and testicular germ cell tumours. Finally, a high TMPRSS4 expression was documented in the olfactory tubercle, paraolfactory gyrus and frontal operculum, all brain regions which are associated with the sense of smell and taste. Collectively, these data suggest that TMPRSS4 may play a role in COVID?19 symptomatology as another SARS?CoV?2 host cell entry mediator responsible for the tropism of this coronavirus both in the periphery and the CNS. Twit Text FOAVip COVID 19 and SARS CoV 2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33649798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33649798 #FOAvip English Wikipedia <ref>{{Cite pmid|33649798}}</ref> COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease #MMPMID33649798 Katopodis P; Kerslake R; Davies J; Randeva HS; Chatha K; Hall M; Spandidos DA; Anikin V; Polychronis A; Robertus JL; Kyrou I; Karteris E Int J Mol Med 2021[Apr]; 47 (4): ä PMID33649798show ga Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2), the causative viral agent for the ongoing COVID?19 pandemic, enters its host cells primarily via the binding of the SARS?CoV?2 spike (S) proteins to the angiotensin?converting enzyme 2 (ACE2). A number of other cell entry mediators have also been identified, including neuropilin?1 (NRP1) and transmembrane protease serine 2 (TMPRSS2). More recently, it has been demonstrated that transmembrane protease serine 4 (TMPRSS4) along with TMPRSS2 activate the SARS?CoV?2 S proteins, and enhance the viral infection of human small intestinal enterocytes. To date, a systematic analysis of TMPRSS4 in health and disease is lacking. In the present study, using in silico tools, the gene expression and genetic alteration of TMPRSS4 were analysed across numerous tumours and compared to controls. The observations were also expanded to the level of the central nervous system (CNS). The findings revealed that TMPRSS4 was overexpressed in 11 types of cancer, including lung adenocarcinoma, lung squamous cell carcinoma, cervical squamous cell carcinoma, thyroid carcinoma, ovarian cancer, cancer of the rectum, pancreatic cancer, colon and stomach adenocarcinoma, uterine carcinosarcoma and uterine corpus endometrial carcinoma, whilst it was significantly downregulated in kidney carcinomas, acute myeloid leukaemia, skin cutaneous melanoma and testicular germ cell tumours. Finally, a high TMPRSS4 expression was documented in the olfactory tubercle, paraolfactory gyrus and frontal operculum, all brain regions which are associated with the sense of smell and taste. Collectively, these data suggest that TMPRSS4 may play a role in COVID?19 symptomatology as another SARS?CoV?2 host cell entry mediator responsible for the tropism of this coronavirus both in the periphery and the CNS. |*Virus Internalization[MESH] |Brain/enzymology[MESH] |COVID-19/*enzymology/*genetics/virology[MESH] |Central Nervous System/enzymology[MESH] |Computer Simulation[MESH] |Databases, Genetic[MESH] |Female[MESH] |Gastrointestinal Tract/enzymology[MESH] |Gene Expression Profiling[MESH] |Host Microbial Interactions/genetics/physiology[MESH] |Humans[MESH] |Male[MESH] |Membrane Proteins/*genetics/physiology[MESH] |Neoplasms/enzymology/genetics[MESH] |Pandemics[MESH] |SARS-CoV-2/*pathogenicity/*physiology[MESH]COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profilin(epmc).pdf DeepDyve Pubget Overpricing