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10.1093/infdis/jiab107 http://scihub22266oqcxt.onion/10.1093/infdis/jiab107 33649773!7989388!33649773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33649773&cmd=llinks): Failed to open stream: HTTP request failed! 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Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19 |pdf=|usr=}}{{33649773}} gab.com Text Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19 JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33649773 #FOAvip BACKGROUND: To better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding and infectivity, we estimated SARS-CoV-2 RNA shedding duration, described participant characteristics associated with the first negative rRT-PCR test (resolution), and determined if replication-competent viruses was recoverable >/=10 days after symptom onset. METHODS: We collected serial nasopharyngeal specimens from 109 individuals with rRT-PCR-confirmed COVID-19 in Utah and Wisconsin. We calculated viral RNA shedding resolution probability using the Kaplan-Meier estimator and evaluated characteristics associated with shedding resolution using Cox proportional hazards regression. We attempted viral culture for 35 rRT-PCR-positive nasopharyngeal specimens collected >/=10 days after symptom onset. RESULTS: The likelihood of viral RNA shedding resolution at 10 days after symptom onset was approximately 3%. Time to shedding resolution was shorter among participants aged <18 years (adjusted hazards ratio [aHR], 3.01; 95% confidence interval [CI], 1.6-5.6) and longer among those aged >/=50 years (aHR, 0.50; 95% CI, .3-.9) compared to participants aged 18-49 years. No replication-competent viruses were recovered. CONCLUSIONS: Although most patients were positive for SARS-CoV-2 for >/=10 days after symptom onset, our findings suggest that individuals with mild to moderate COVID-19 are unlikely to be infectious >/=10 days after symptom onset. Twit Text FOAVip Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19 ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33649773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33649773 #FOAvip English Wikipedia <ref>{{Cite pmid|33649773}}</ref> Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19 #MMPMID33649773 Owusu D; Pomeroy MA; Lewis NM; Wadhwa A; Yousaf AR; Whitaker B; Dietrich E; Hall AJ; Chu V; Thornburg N; Christensen K; Kiphibane T; Willardson S; Westergaard R; Dasu T; Pray IW; Bhattacharyya S; Dunn A; Tate JE; Kirking HL; Matanock A J Infect Dis 2021[Oct]; 224 (8): 1362-1371 PMID33649773show ga BACKGROUND: To better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding and infectivity, we estimated SARS-CoV-2 RNA shedding duration, described participant characteristics associated with the first negative rRT-PCR test (resolution), and determined if replication-competent viruses was recoverable >/=10 days after symptom onset. METHODS: We collected serial nasopharyngeal specimens from 109 individuals with rRT-PCR-confirmed COVID-19 in Utah and Wisconsin. We calculated viral RNA shedding resolution probability using the Kaplan-Meier estimator and evaluated characteristics associated with shedding resolution using Cox proportional hazards regression. We attempted viral culture for 35 rRT-PCR-positive nasopharyngeal specimens collected >/=10 days after symptom onset. RESULTS: The likelihood of viral RNA shedding resolution at 10 days after symptom onset was approximately 3%. Time to shedding resolution was shorter among participants aged <18 years (adjusted hazards ratio [aHR], 3.01; 95% confidence interval [CI], 1.6-5.6) and longer among those aged >/=50 years (aHR, 0.50; 95% CI, .3-.9) compared to participants aged 18-49 years. No replication-competent viruses were recovered. CONCLUSIONS: Although most patients were positive for SARS-CoV-2 for >/=10 days after symptom onset, our findings suggest that individuals with mild to moderate COVID-19 are unlikely to be infectious >/=10 days after symptom onset. |*Virus Shedding[MESH] |Adolescent[MESH] |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/diagnosis/*transmission/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Contact Tracing[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/pathology/virology[MESH] |RNA, Viral/*isolation & purification[MESH] |SARS-CoV-2/genetics/isolation & purification/*pathogenicity[MESH] |Time Factors[MESH] |Virus Replication[MESH]Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness:(epmc).pdf DeepDyve Pubget Overpricing