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10.1016/j.xcrm.2021.100221 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100221 33649748!7904449!33649748     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (3): 100221 Nephropedia Template TP {{tp|p=33649748|t=2021. Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2 |pdf=|usr=}}{{33649748}} gab.com Text Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33649748 #FOAvip Polymorphisms in MHC-I protein sequences across human populations significantly affect viral peptide binding capacity, and thus alter T cell immunity to infection. In the present study, we assess the relationship between observed SARS-CoV-2 population mortality and the predicted viral binding capacities of 52 common MHC-I alleles. Potential SARS-CoV-2 MHC-I peptides are identified using a consensus MHC-I binding and presentation prediction algorithm called EnsembleMHC. Starting with nearly 3.5 million candidates, we resolve a few hundred highly probable MHC-I peptides. By weighing individual MHC allele-specific SARS-CoV-2 binding capacity with population frequency in 23 countries, we discover a strong inverse correlation between predicted population SARS-CoV-2 peptide binding capacity and mortality rate. Our computations reveal that peptides derived from the structural proteins of the virus produce a stronger association with observed mortality rate, highlighting the importance of S, N, M, and E proteins in driving productive immune responses. Twit Text FOAVip Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33649748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33649748 #FOAvip English Wikipedia <ref>{{Cite pmid|33649748}}</ref> Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2 #MMPMID33649748 Wilson EA; Hirneise G; Singharoy A; Anderson KS Cell Rep Med 2021[Mar]; 2 (3): 100221 PMID33649748show ga Polymorphisms in MHC-I protein sequences across human populations significantly affect viral peptide binding capacity, and thus alter T cell immunity to infection. In the present study, we assess the relationship between observed SARS-CoV-2 population mortality and the predicted viral binding capacities of 52 common MHC-I alleles. Potential SARS-CoV-2 MHC-I peptides are identified using a consensus MHC-I binding and presentation prediction algorithm called EnsembleMHC. Starting with nearly 3.5 million candidates, we resolve a few hundred highly probable MHC-I peptides. By weighing individual MHC allele-specific SARS-CoV-2 binding capacity with population frequency in 23 countries, we discover a strong inverse correlation between predicted population SARS-CoV-2 peptide binding capacity and mortality rate. Our computations reveal that peptides derived from the structural proteins of the virus produce a stronger association with observed mortality rate, highlighting the importance of S, N, M, and E proteins in driving productive immune responses. |Algorithms[MESH] |Alleles[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19/*mortality/pathology/virology[MESH] |Cell Line, Tumor[MESH] |Epitopes, T-Lymphocyte/chemistry/*immunology[MESH] |Gene Frequency[MESH] |Histocompatibility Antigens Class I/chemistry/genetics/*immunology[MESH] |Humans[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH]Total predicted MHC-I epitope load is inversely associated with popula(epmc).pdf DeepDyve Pubget Overpricing