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10.1016/j.cjco.2021.02.012

http://scihub22266oqcxt.onion/10.1016/j.cjco.2021.02.012
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suck abstract from ncbi


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pmid33649742      CJC+Open 2021 ; 3 (7): 880-887
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  • Detailed Assessment of Left Ventricular Function in Multisystem Inflammatory Syndrome in Children, Using Strain Analysis #MMPMID33649742
  • Kobayashi R; Dionne A; Ferraro A; Harrild D; Newburger J; VanderPluym C; Gauvreau K; Son MB; Lee P; Baker A; de Ferranti S; Friedman KG
  • CJC Open 2021[Jul]; 3 (7): 880-887 PMID33649742show ga
  • BACKGROUND: Cardiac manifestations in multisystem inflammatory syndrome in children (MIS-C) occur in approximately 80% of patients. Left ventricular (LV) systolic dysfunction is the most frequent cardiac finding. METHODS: In this single-centre, retrospective cohort study, we report on detailed assessment of LV function in MIS-C patients using strain and strain rate analysis. We compare those with normal peak systolic strain z-scores (both longitudinal and circumferential strain) to those with abnormal peak systolic strain z-scores (decreased circumferential and/or longitudinal strain). RESULTS: Among 25 patients, 14 (56%) were male, 20 (80%) were Black or Hispanic, 13 (52%) were overweight/obese, and the median age was 11.4 years (interquartile range: 7.5 to 16). Median ejection fraction (EF) was 55.2% (interquartile range: 48.3% to 58%), with the abnormal strain patients having a lower EF (P < 0.01). Demographics were similar between groups. The abnormal strain patients had more organ systems involved and were more likely to require inotropic support. In a comparison of MIS-C patients with normal EF (n = 15) to controls, MIS-C patients had lower peak systolic strain as well as lower early diastolic strain rates. In patients with initially depressed function, EF normalized in 8 of 10 (80%), but 4 of 11 (36%) patients had persistently abnormal systolic strain after discharge. CONCLUSIONS: LV systolic dysfunction is common in the acute phase of MIS-C, and detection may be improved with strain imaging. Longitudinal cardiac follow-up is imperative, as some patients may be at risk for persistent LV dysfunction.
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