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10.1038/s41431-021-00831-y http://scihub22266oqcxt.onion/10.1038/s41431-021-00831-y 33649539!7917374!33649539     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Hum+Genet 2021 ; 29 (6): 1019-1026 Nephropedia Template TP {{tp|p=33649539|t=2021. Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants |pdf=|usr=}}{{33649539}} gab.com Text Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants JO: Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33649539 #FOAvip Germline variants in genes involved in SARS-CoV-2 cell entry and in host innate immune responses to viruses may influence the susceptibility to infection. This study used whole-genome analyses of lung tissue to identify polymorphisms acting as expression quantitative trait loci (eQTLs) for 60 genes of relevance to SARS-CoV-2 infection susceptibility. The expression of genes with confirmed or possible roles in viral entry-replication and in host antiviral responses was studied in the non-diseased lung tissue of 408 lung adenocarcinoma patients. No gene was differently expressed by sex, but APOBEC3H levels were higher and PARP12 levels lower in older individuals. A total of 125 cis-eQTLs (false discovery rate < 0.05) was found to modulate mRNA expression of 15 genes (ABO, ANPEP, AP2A2, APOBEC3D, APOBEC3G, BSG, CLEC4G, DDX58, DPP4, FURIN, FYCO1, RAB14, SERINC3, TRIM5, ZCRB1). eQTLs regulating ABO and FYCO1 were found in COVID-19 susceptibility loci. No trans-eQTLs were identified. Genetic control of the expression of these 15 genes, which encode putative virus receptors, proteins required for vesicle trafficking, enzymes that interfere with viral replication, and other restriction factors, may underlie interindividual differences in risk or severity of infection with SARS-CoV-2 or other viruses. Twit Text FOAVip Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants ????Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33649539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33649539 #FOAvip English Wikipedia <ref>{{Cite pmid|33649539}}</ref> Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants #MMPMID33649539 Cotroneo CE; Mangano N; Dragani TA; Colombo F Eur J Hum Genet 2021[Jun]; 29 (6): 1019-1026 PMID33649539show ga Germline variants in genes involved in SARS-CoV-2 cell entry and in host innate immune responses to viruses may influence the susceptibility to infection. This study used whole-genome analyses of lung tissue to identify polymorphisms acting as expression quantitative trait loci (eQTLs) for 60 genes of relevance to SARS-CoV-2 infection susceptibility. The expression of genes with confirmed or possible roles in viral entry-replication and in host antiviral responses was studied in the non-diseased lung tissue of 408 lung adenocarcinoma patients. No gene was differently expressed by sex, but APOBEC3H levels were higher and PARP12 levels lower in older individuals. A total of 125 cis-eQTLs (false discovery rate < 0.05) was found to modulate mRNA expression of 15 genes (ABO, ANPEP, AP2A2, APOBEC3D, APOBEC3G, BSG, CLEC4G, DDX58, DPP4, FURIN, FYCO1, RAB14, SERINC3, TRIM5, ZCRB1). eQTLs regulating ABO and FYCO1 were found in COVID-19 susceptibility loci. No trans-eQTLs were identified. Genetic control of the expression of these 15 genes, which encode putative virus receptors, proteins required for vesicle trafficking, enzymes that interfere with viral replication, and other restriction factors, may underlie interindividual differences in risk or severity of infection with SARS-CoV-2 or other viruses. |*Genetic Predisposition to Disease[MESH] |ABO Blood-Group System/*genetics[MESH] |COVID-19/*genetics/virology[MESH] |Galactosyltransferases/*genetics[MESH] |Gene Expression Regulation/genetics[MESH] |Humans[MESH] |Immunity, Innate/genetics[MESH] |Lung/metabolism/pathology[MESH] |Microtubule-Associated Proteins/*genetics[MESH] |Polymorphism, Genetic[MESH] |Quantitative Trait Loci/genetics[MESH] |Receptors, Virus/genetics[MESH]Lung expression of genes putatively involved in SARS-CoV-2 infection i(epmc).pdf DeepDyve Pubget Overpricing