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10.1038/s41467-021-21634-1 http://scihub22266oqcxt.onion/10.1038/s41467-021-21634-1 33649323!7921634!33649323     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1346 Nephropedia Template TP {{tp|p=33649323|t=2021. S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates |pdf=|usr=}}{{33649323}} gab.com Text S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33649323 #FOAvip SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses. Twit Text FOAVip S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33649323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33649323 #FOAvip English Wikipedia <ref>{{Cite pmid|33649323}}</ref> S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates #MMPMID33649323 Liang JG; Su D; Song TZ; Zeng Y; Huang W; Wu J; Xu R; Luo P; Yang X; Zhang X; Luo S; Liang Y; Li X; Huang J; Wang Q; Huang X; Xu Q; Luo M; Huang A; Luo D; Zhao C; Yang F; Han JB; Zheng YT; Liang P Nat Commun 2021[Mar]; 12 (1): 1346 PMID33649323show ga SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses. |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Blotting, Western[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Vaccines/*therapeutic use[MESH] |COVID-19/*immunology/*prevention & control/therapy[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Humans[MESH] |Immunity, Cellular/physiology[MESH] |Immunization, Passive[MESH] |Immunohistochemistry[MESH] |Macaca mulatta[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Microscopy, Electron[MESH]S-Trimer, a COVID-19 subunit vaccine candidate, induces protective imm(epmc).pdf DeepDyve Pubget Overpricing