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10.1158/1078-0432.CCR-20-4750 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-20-4750 33648989!8127351!33648989     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2021 ; 27 (10): 2706-2711 Nephropedia Template TP {{tp|p=33648989|t=2021. Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer |pdf=|usr=}}{{33648989}} gab.com Text Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=33648989 #FOAvip The dramatic impact of the COVID-19 pandemic has resulted in an "all hands on deck" approach to find new therapies to improve outcomes in this disease. In addition to causing significant respiratory pathology, infection with SARS-CoV-2 (like infection with other respiratory viruses) directly or indirectly results in abnormal vasculature, which may contribute to hypoxemia. These vascular effects cause significant morbidity and may contribute to mortality from the disease. Given that abnormal vasculature and poor oxygenation are also hallmarks of solid tumors, lessons from the treatment of cancer may help identify drugs that can be repurposed to treat COVID-19. Although the mechanisms that result in vascular abnormalities in COVID-19 are not fully understood, it is possible that there is dysregulation of many of the same angiogenic and thrombotic pathways as seen in patients with cancer. Many anticancer therapeutics, including androgen deprivation therapy (ADT) and immune checkpoint blockers (ICB), result in vascular normalization in addition to their direct effects on tumor cells. Therefore, these therapies, which have been extensively explored in clinical trials of patients with cancer, may have beneficial effects on the vasculature of patients with COVID-19. Furthermore, these drugs may have additional effects on the disease course, as some ADTs may impact viral entry, and ICBs may accelerate T-cell-mediated viral clearance. These insights from the treatment of cancer may be leveraged to abrogate the vascular pathologies found in COVID-19 and other forms of hypoxemic respiratory failure. Twit Text FOAVip Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=33648989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33648989 #FOAvip English Wikipedia <ref>{{Cite pmid|33648989}}</ref> Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer #MMPMID33648989 Munn LL; Stylianopoulos T; Jain NK; Hardin CC; Khandekar MJ; Jain RK Clin Cancer Res 2021[May]; 27 (10): 2706-2711 PMID33648989show ga The dramatic impact of the COVID-19 pandemic has resulted in an "all hands on deck" approach to find new therapies to improve outcomes in this disease. In addition to causing significant respiratory pathology, infection with SARS-CoV-2 (like infection with other respiratory viruses) directly or indirectly results in abnormal vasculature, which may contribute to hypoxemia. These vascular effects cause significant morbidity and may contribute to mortality from the disease. Given that abnormal vasculature and poor oxygenation are also hallmarks of solid tumors, lessons from the treatment of cancer may help identify drugs that can be repurposed to treat COVID-19. Although the mechanisms that result in vascular abnormalities in COVID-19 are not fully understood, it is possible that there is dysregulation of many of the same angiogenic and thrombotic pathways as seen in patients with cancer. Many anticancer therapeutics, including androgen deprivation therapy (ADT) and immune checkpoint blockers (ICB), result in vascular normalization in addition to their direct effects on tumor cells. Therefore, these therapies, which have been extensively explored in clinical trials of patients with cancer, may have beneficial effects on the vasculature of patients with COVID-19. Furthermore, these drugs may have additional effects on the disease course, as some ADTs may impact viral entry, and ICBs may accelerate T-cell-mediated viral clearance. These insights from the treatment of cancer may be leveraged to abrogate the vascular pathologies found in COVID-19 and other forms of hypoxemic respiratory failure. |Androgen Antagonists/*therapeutic use[MESH] |Blood Vessels/*drug effects/pathology/physiopathology[MESH] |COVID-19/epidemiology/*prevention & control/virology[MESH] |Clinical Trials as Topic[MESH] |Disease Progression[MESH] |Humans[MESH] |Male[MESH] |Neoplasms, Hormone-Dependent/blood supply/*drug therapy[MESH] |Neovascularization, Pathologic/*drug therapy[MESH] |Outcome Assessment, Health Care[MESH] |Pandemics[MESH] |Prostatic Neoplasms/blood supply/*drug therapy[MESH] |Risk Factors[MESH]Vascular Normalization to Improve Treatment of COVID-19: Lessons from (epmc).pdf DeepDyve Pubget Overpricing