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10.1016/j.ejphar.2021.173982 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2021.173982 33647257!ä!33647257 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 898 (ä): 173982 Nephropedia Template TP {{tp|p=33647257|t=2021. Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway |pdf=|usr=}}{{33647257}} gab.com Text Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33647257 #FOAvip Liver fibrosis is a compensatory response to the tissue repair process. The activation and proliferation of hepatic stellate cells (HSCs) are thought to be related to the occurrence of hepatic fibrosis. Therefore, inhibiting the activation and proliferation of HSCs is a key step in alleviating liver fibrosis. As a non-specific inhibitor of transient receptor potential melastatin 7 (TRPM7), carvacrol has anti-tumor, anti-inflammatory and anti-hepatic fibrosis activities. This study aimed to explore the protective effect of carvacrol on liver fibrosis and related molecular mechanisms. A CCl(4)-induced liver fibrosis mouse model and platelet-derived growth factor (PDGF-BB)-activated HSC-T6 cells (a rat hepatic stellate cell line) were employed for in vivo and in vitro experiments. C57BL/6J mice were orally administered different concentrations of carvacrol every day for 6 weeks during the development of CCl(4)-induced liver fibrosis. The results show that carvacrol could effectively reduce liver damage and the progression of liver fibrosis in mice, which are expressed as fibrotic markers levels were reduced and histopathological characteristics were improved. Moreover, carvacrol inhibited the proliferation and activation of HSC-T6 cells induced by PDGF-BB. In addition, it was found that carvacrol inhibits the expression of TRPM7 and mediated through mitogen-activated protein kinases (MAPK). Collectively, our study shows that carvacrol can reduce liver fibrosis by inhibiting the activation and proliferation of hepatic stellate cells, and the MAPK signaling pathway might be involved in this process. Twit Text FOAVip Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33647257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33647257 #FOAvip English Wikipedia <ref>{{Cite pmid|33647257}}</ref> Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway #MMPMID33647257 Cai S; Wu L; Yuan S; Liu G; Wang Y; Fang L; Xu D Eur J Pharmacol 2021[May]; 898 (ä): 173982 PMID33647257show ga Liver fibrosis is a compensatory response to the tissue repair process. The activation and proliferation of hepatic stellate cells (HSCs) are thought to be related to the occurrence of hepatic fibrosis. Therefore, inhibiting the activation and proliferation of HSCs is a key step in alleviating liver fibrosis. As a non-specific inhibitor of transient receptor potential melastatin 7 (TRPM7), carvacrol has anti-tumor, anti-inflammatory and anti-hepatic fibrosis activities. This study aimed to explore the protective effect of carvacrol on liver fibrosis and related molecular mechanisms. A CCl(4)-induced liver fibrosis mouse model and platelet-derived growth factor (PDGF-BB)-activated HSC-T6 cells (a rat hepatic stellate cell line) were employed for in vivo and in vitro experiments. C57BL/6J mice were orally administered different concentrations of carvacrol every day for 6 weeks during the development of CCl(4)-induced liver fibrosis. The results show that carvacrol could effectively reduce liver damage and the progression of liver fibrosis in mice, which are expressed as fibrotic markers levels were reduced and histopathological characteristics were improved. Moreover, carvacrol inhibited the proliferation and activation of HSC-T6 cells induced by PDGF-BB. In addition, it was found that carvacrol inhibits the expression of TRPM7 and mediated through mitogen-activated protein kinases (MAPK). Collectively, our study shows that carvacrol can reduce liver fibrosis by inhibiting the activation and proliferation of hepatic stellate cells, and the MAPK signaling pathway might be involved in this process. |Animals[MESH] |Becaplermin/pharmacology[MESH] |Carbon Tetrachloride[MESH] |Cell Line[MESH] |Cell Proliferation/drug effects[MESH] |Chemical and Drug Induced Liver Injury/enzymology/etiology/pathology/*prevention & control[MESH] |Collagen/metabolism[MESH] |Cymenes/*pharmacology[MESH] |Hepatic Stellate Cells/*drug effects/enzymology/pathology[MESH] |Liver Cirrhosis, Experimental/chemically induced/enzymology/pathology/*prevention & control[MESH] |Liver/*drug effects/enzymology/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mitogen-Activated Protein Kinases/*metabolism[MESH] |Rats[MESH] |Signal Transduction[MESH]Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating(epmc).pdf DeepDyve Pubget Overpricing