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10.1084/jem.20202617 http://scihub22266oqcxt.onion/10.1084/jem.20202617 33646265!7927662!33646265     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2021 ; 218 (5): ä Nephropedia Template TP {{tp|p=33646265|t=2021. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection |pdf=|usr=}}{{33646265}} gab.com Text Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33646265 #FOAvip The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SARS-CoV-2-specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion. We quantified T cells reactive to structural proteins (M, NP, and Spike) using ELISpot and cytokine secretion in whole blood. Frequencies of SARS-CoV-2-specific T cells were similar between asymptomatic and symptomatic individuals, but the former showed an increased IFN-gamma and IL-2 production. This was associated with a proportional secretion of IL-10 and proinflammatory cytokines (IL-6, TNF-alpha, and IL-1beta) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2-specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2-infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response. Twit Text FOAVip Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33646265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33646265 #FOAvip English Wikipedia <ref>{{Cite pmid|33646265}}</ref> Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection #MMPMID33646265 Le Bert N; Clapham HE; Tan AT; Chia WN; Tham CYL; Lim JM; Kunasegaran K; Tan LWL; Dutertre CA; Shankar N; Lim JME; Sun LJ; Zahari M; Tun ZM; Kumar V; Lim BL; Lim SH; Chia A; Tan YJ; Tambyah PA; Kalimuddin S; Lye D; Low JGH; Wang LF; Wan WY; Hsu LY; Bertoletti A; Tam CC J Exp Med 2021[May]; 218 (5): ä PMID33646265show ga The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SARS-CoV-2-specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion. We quantified T cells reactive to structural proteins (M, NP, and Spike) using ELISpot and cytokine secretion in whole blood. Frequencies of SARS-CoV-2-specific T cells were similar between asymptomatic and symptomatic individuals, but the former showed an increased IFN-gamma and IL-2 production. This was associated with a proportional secretion of IL-10 and proinflammatory cytokines (IL-6, TNF-alpha, and IL-1beta) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2-specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2-infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response. |*Asymptomatic Infections[MESH] |*Lymphocyte Activation[MESH] |Adult[MESH] |COVID-19/blood/*immunology[MESH] |Cytokines/blood/*immunology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology/metabolism[MESH]Highly functional virus-specific cellular immune response in asymptoma(epmc).pdf DeepDyve Pubget Overpricing