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10.1021/acs.analchem.0c02971 http://scihub22266oqcxt.onion/10.1021/acs.analchem.0c02971 33645217!ä!33645217 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anal+Chem 2021 ; 93 (9): 4154-4159 Nephropedia Template TP {{tp|p=33645217|t=2021. Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveguides |pdf=|usr=}}{{33645217}} gab.com Text Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveguides JO: Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=33645217 #FOAvip Chip-scale SARS-CoV-2 testing was demonstrated using silicon nitride (Si(3)N(4)) nanoslot fluidic waveguides to detect a tagged oligonucleotide with a coronavirus DNA sequence. The slot waveguides were fabricated using complementary metal-oxide-semiconductor (CMOS) fabrication processes, including multiscale lithography and selective reactive ion etching (RIE), forming femtoliter fluidic channels. Finite difference method (FDM) simulation was used to calculate the optical field distribution of the waveguide mode when the waveguide sensor was excited by transverse electric (TE) and transverse magnetic (TM) polarized light. For the TE polarization, a strong optical field was created in the slot region and its field intensity was 14x stronger than the evanescent sensing field from the TM polarization. The nanoscale confinement of the optical sensing field significantly enhanced the light-analyte interaction and improved the optical sensitivity. The sensitivity enhancement was experimentally demonstrated by measuring the polarization-dependent fluorescence emission from the tagged oligonucleotide. The photonic chips consisting of femtoliter Si(3)N(4) waveguides provide a low-cost and high throughput platform for real-time virus identification, which is critical for point-of-care (PoC) diagnostic applications. Twit Text FOAVip Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveguides ????Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=33645217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33645217 #FOAvip English Wikipedia <ref>{{Cite pmid|33645217}}</ref> Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveguides #MMPMID33645217 Makela M; Lin PT Anal Chem 2021[Mar]; 93 (9): 4154-4159 PMID33645217show ga Chip-scale SARS-CoV-2 testing was demonstrated using silicon nitride (Si(3)N(4)) nanoslot fluidic waveguides to detect a tagged oligonucleotide with a coronavirus DNA sequence. The slot waveguides were fabricated using complementary metal-oxide-semiconductor (CMOS) fabrication processes, including multiscale lithography and selective reactive ion etching (RIE), forming femtoliter fluidic channels. Finite difference method (FDM) simulation was used to calculate the optical field distribution of the waveguide mode when the waveguide sensor was excited by transverse electric (TE) and transverse magnetic (TM) polarized light. For the TE polarization, a strong optical field was created in the slot region and its field intensity was 14x stronger than the evanescent sensing field from the TM polarization. The nanoscale confinement of the optical sensing field significantly enhanced the light-analyte interaction and improved the optical sensitivity. The sensitivity enhancement was experimentally demonstrated by measuring the polarization-dependent fluorescence emission from the tagged oligonucleotide. The photonic chips consisting of femtoliter Si(3)N(4) waveguides provide a low-cost and high throughput platform for real-time virus identification, which is critical for point-of-care (PoC) diagnostic applications. |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis/*virology[MESH] |DNA, Viral/*analysis[MESH] |Humans[MESH] |Nanoparticles/*chemistry[MESH] |Optics and Photonics[MESH] |Point-of-Care Systems[MESH] |Refractometry[MESH] |SARS-CoV-2/*genetics/*isolation & purification[MESH] |Semiconductors[MESH] |Sensitivity and Specificity[MESH]Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveg(epmc).pdf DeepDyve Pubget Overpricing