Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2021.574425 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.574425 33643308!7906979!33643308     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 574425 Nephropedia Template TP {{tp|p=33643308|t=2021. Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19 |pdf=|usr=}}{{33643308}} gab.com Text Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33643308 #FOAvip The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support the premise of targeting the immune response. However, because suppressing immune mechanisms could also impact the clearance of the virus in the early stages of infection, therapeutic success is likely to depend on timing with respect to the disease course. Azithromycin is an immunomodulatory drug that has been shown to have antiviral effects and potential benefit in patients with COVID-19. Multiple immunomodulatory effects have been defined for azithromycin which could provide efficacy during the late stages of the disease, including inhibition of pro-inflammatory cytokine production, inhibition of neutrophil influx, induction of regulatory functions of macrophages, and alterations in autophagy. Here we review the published evidence of these mechanisms along with the current clinical use of azithromycin as an immunomodulatory therapeutic. We then discuss the potential impact of azithromycin on the immune response to COVID-19, as well as caution against immunosuppressive and off-target effects including cardiotoxicity in these patients. While azithromycin has the potential to contribute efficacy, its impact on the COVID-19 immune response requires additional characterization so as to better define its role in individualized therapy. Twit Text FOAVip Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33643308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33643308 #FOAvip English Wikipedia <ref>{{Cite pmid|33643308}}</ref> Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19 #MMPMID33643308 Venditto VJ; Haydar D; Abdel-Latif A; Gensel JC; Anstead MI; Pitts MG; Creameans J; Kopper TJ; Peng C; Feola DJ Front Immunol 2021[]; 12 (ä): 574425 PMID33643308show ga The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support the premise of targeting the immune response. However, because suppressing immune mechanisms could also impact the clearance of the virus in the early stages of infection, therapeutic success is likely to depend on timing with respect to the disease course. Azithromycin is an immunomodulatory drug that has been shown to have antiviral effects and potential benefit in patients with COVID-19. Multiple immunomodulatory effects have been defined for azithromycin which could provide efficacy during the late stages of the disease, including inhibition of pro-inflammatory cytokine production, inhibition of neutrophil influx, induction of regulatory functions of macrophages, and alterations in autophagy. Here we review the published evidence of these mechanisms along with the current clinical use of azithromycin as an immunomodulatory therapeutic. We then discuss the potential impact of azithromycin on the immune response to COVID-19, as well as caution against immunosuppressive and off-target effects including cardiotoxicity in these patients. While azithromycin has the potential to contribute efficacy, its impact on the COVID-19 immune response requires additional characterization so as to better define its role in individualized therapy. |*COVID-19 Drug Treatment[MESH] |Azithromycin/*therapeutic use[MESH] |Cytokines/metabolism[MESH] |Humans[MESH] |Immunomodulation[MESH] |Inflammation/*drug therapy[MESH] |Neutrophils/*immunology[MESH] |Pandemics[MESH]Immunomodulatory Effects of Azithromycin Revisited: Potential Applicat(epmc).pdf DeepDyve Pubget Overpricing