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10.7883/yoken.JJID.2020.799

http://scihub22266oqcxt.onion/10.7883/yoken.JJID.2020.799
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33642431!ä!33642431

suck abstract from ncbi


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pmid33642431      Jpn+J+Infect+Dis 2021 ; 74 (6): 560-562
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  • Early Anti-SARS-CoV-2 Immunoglobulin G Response May Be Associated with Disease Severity in Patients with COVID-19 #MMPMID33642431
  • Maeda T; Kashiwagi K; Yoshizawa S; Sato T; Aoki K; Ishii Y; Tateda K
  • Jpn J Infect Dis 2021[Nov]; 74 (6): 560-562 PMID33642431show ga
  • Most coronavirus disease 2019 (COVID-19) cases are mild or asymptomatic, and a substantial minority of patients have severe or critical diseases. There are several reports on the potential risk factors of severe disease, but few reports have reported a relationship between antibody titer and severity in Japan. Antibody-dependent enhancement affects disease progression. We evaluated the IgG responses in COVID-19 patients at our tertiary hospital. The IgG index was the measure of interest. We assigned 1.4 as the cutoff value for a positive result based on the specifications by the manufacturer and observed that patients could be categorized into two groups: the early elevation of IgG and late elevation of IgG (IgG elevated in the first 7 days +/- 2 days or more than 10 days after symptom onset) groups. The former comprised early IgG responders (n = 7) and the latter comprised late IgG responders (n = 14), and they were compared. The C-reactive protein and D-dimer concentrations were significantly higher in the early IgG responders on admission (HD 0). The respiratory rate was also higher. The lymphocytes were significantly fewer on day 7 of hospitalization (HD 7). These results suggest that early production of anti-severe acute respiratory syndrome coronavirus 2 IgG may be associated with clinical indicators of severity.
  • |*COVID-19/immunology/pathology[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*immunology[MESH]
  • |Japan[MESH]


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