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10.1016/j.regg.2021.02.001

http://scihub22266oqcxt.onion/10.1016/j.regg.2021.02.001
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suck abstract from ncbi


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pmid33642133      Rev+Esp+Geriatr+Gerontol 2021 ; 56 (3): 177-182
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  • VitaminD supplementation for the prevention and treatment of COVID-19: a position statement from the Spanish Society of Geriatrics and Gerontology #MMPMID33642133
  • Tarazona-Santabalbina FJ; Cuadra L; Cancio JM; Carbonell FR; Garrote JMP; Casas-Herrero A; Martinez-Velilla N; Serra-Rexach JA; Formiga F
  • Rev Esp Geriatr Gerontol 2021[May]; 56 (3): 177-182 PMID33642133show ga
  • The coronavirus disease 2019 (COVID-19) produces severe respiratory symptoms such as bilateral pneumonia associated to a high morbidity and mortality, especially in patients of advanced age. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and dysregulation of the immune system. Vitamin D in modulates immune function too. Vitamin D receptor (VDR) is expressed by most immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells and the signalling of vitamin D and VDR together has an anti-inflammatory effect. Some studies have reported that vitamin D treatment could be useful for the prevention and treatment of COVID-19 because vitamin D plays an important role as a modulator of immunocompetence. Over the last few months, some studies have hypothesized the possible beneficial effect of vitamin D supplementation in patients with COVID-19 in order to improve the immune balance and prevent the hyperinflammatory cytokine storm. Some preliminary studies have already shown promising results with vitamin D supplementation in hospitalized COVID-19 patients. Vitamin D should be administered daily until adequate levels are achieved due to vitamin D behaves as a negative acute phase reactant (APR). Despite the lack of evidence on specific doses of vitamin D to treat COVID-19 in older adults, authors consider it is necessary to standardize the use in clinical practice. These recommendations advice supplement vitamin D in a protocoled fashion based on expert opinions, level of evidence 5.
  • |*Cytokine Release Syndrome/prevention & control[MESH]
  • |*Dietary Supplements[MESH]
  • |*Geriatrics[MESH]
  • |Aged[MESH]
  • |COVID-19/complications/immunology/prevention & control/*therapy[MESH]
  • |Humans[MESH]
  • |Receptors, Calcitriol/metabolism[MESH]
  • |Societies, Medical[MESH]
  • |Spain[MESH]
  • |Vitamin D Deficiency/complications/*therapy[MESH]
  • |Vitamin D/*administration & dosage/immunology[MESH]


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