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10.1016/j.fct.2021.112087

http://scihub22266oqcxt.onion/10.1016/j.fct.2021.112087
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suck abstract from ncbi


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pmid33640537      Food+Chem+Toxicol 2021 ; 150 (ä): 112087
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  • Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review #MMPMID33640537
  • Smail SW; Saeed M; Twana Alkasalias; Khudhur ZO; Younus DA; Rajab MF; Abdulahad WH; Hussain HI; Niaz K; Safdar M
  • Food Chem Toxicol 2021[Apr]; 150 (ä): 112087 PMID33640537show ga
  • Coronavirus disease-19 (COVID-19) is a complex disease that causes illness ranging from mild to severe respiratory problems. It is caused by a novel coronavirus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) that is an enveloped positive-sense single-stranded RNA (+ssRNA) virus belongs to coronavirus CoV family. It has a fast-spreading potential worldwide, which leads to high mortality regardless of lows death rates. Now some vaccines or a specific drug are approved but not available for every country for disease prevention and/or treatment. Therefore, it is a high demand to identify the known drugs and test them as a possible therapeutic approach. In this critical situation, one or more of these drugs may represent the only option to treat or reduce the severity of the disease, until some specific drugs or vaccines will be developed and/or approved for everyone in this pandemic. In this updated review, the available repurpose immunotherapeutic treatment strategies are highlighted, elucidating the crosstalk between the immune system and SARS-CoV-2. Despite the reasonable data availability, the effectiveness and safety of these drugs against SARS-CoV-2 needs further studies and validations aiming for a better clinical outcome.
  • |Adrenal Cortex Hormones/pharmacology/therapeutic use[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic use[MESH]
  • |Antibodies, Monoclonal/immunology/pharmacology/therapeutic use[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/immunology/virology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy/*etiology/immunology[MESH]
  • |Interferons/pharmacology/therapeutic use[MESH]
  • |Janus Kinase Inhibitors/pharmacology/therapeutic use[MESH]


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