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10.1186/s13578-021-00564-x http://scihub22266oqcxt.onion/10.1186/s13578-021-00564-x 33640032!7914117!33640032     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biosci 2021 ; 11 (1): 45 Nephropedia Template TP {{tp|p=33640032|t=2021. Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases |pdf=|usr=}}{{33640032}} gab.com Text Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=33640032 #FOAvip BACKGROUND: In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. RESULTS: We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PL(pro)). Moreover, our study demonstrated that the two hit compounds are dual inhibitors targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)) in addition to PL(pro). A mechanism of action study using enzyme kinetics further characterized the two compounds as irreversible inhibitors against both 3CL(pro) and PL(pro). Significantly, both identified compounds inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations. CONCLUSIONS: Our finding provides two novel natural products as promising SARS-CoV-2 antivirals. Twit Text FOAVip Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=33640032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33640032 #FOAvip English Wikipedia <ref>{{Cite pmid|33640032}}</ref> Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases #MMPMID33640032 Chen Z; Cui Q; Cooper L; Zhang P; Lee H; Chen Z; Wang Y; Liu X; Rong L; Du R Cell Biosci 2021[Feb]; 11 (1): 45 PMID33640032show ga BACKGROUND: In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. RESULTS: We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PL(pro)). Moreover, our study demonstrated that the two hit compounds are dual inhibitors targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)) in addition to PL(pro). A mechanism of action study using enzyme kinetics further characterized the two compounds as irreversible inhibitors against both 3CL(pro) and PL(pro). Significantly, both identified compounds inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations. CONCLUSIONS: Our finding provides two novel natural products as promising SARS-CoV-2 antivirals. äGinkgolic acid and anacardic acid are specific covalent inhibitors of (epmc).pdf DeepDyve Pubget Overpricing