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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Biosci 2021 ; 11 (1): 45 Nephropedia Template TP
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Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases #MMPMID33640032
Chen Z; Cui Q; Cooper L; Zhang P; Lee H; Chen Z; Wang Y; Liu X; Rong L; Du R
Cell Biosci 2021[Feb]; 11 (1): 45 PMID33640032show ga
BACKGROUND: In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. RESULTS: We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2 papain-like protease (PL(pro)). Moreover, our study demonstrated that the two hit compounds are dual inhibitors targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)) in addition to PL(pro). A mechanism of action study using enzyme kinetics further characterized the two compounds as irreversible inhibitors against both 3CL(pro) and PL(pro). Significantly, both identified compounds inhibit SARS-CoV-2 replication in vitro at nontoxic concentrations. CONCLUSIONS: Our finding provides two novel natural products as promising SARS-CoV-2 antivirals.