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10.1016/j.clim.2021.108699 http://scihub22266oqcxt.onion/10.1016/j.clim.2021.108699 33639276!7904470!33639276     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2021 ; 226 (ä): 108699 Nephropedia Template TP {{tp|p=33639276|t=2021. The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection |pdf=|usr=}}{{33639276}} gab.com Text The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33639276 #FOAvip RNA editing is a fundamental biological process with 2 major forms, namely adenosine-to-inosine (A-to-I, recognized as A-to-G) and cytosine-to-uracil (C-to-U) deamination, mediated by ADAR and APOBEC enzyme families, respectively. A-to-I RNA editing has been shown to directly affect the genome/transcriptome of RNA viruses with significant repercussions for viral protein synthesis, proliferation and infectivity, while it also affects recognition of double-stranded RNAs by cytosolic receptors controlling the host innate immune response. Recent evidence suggests that RNA editing may be present in SARS-CoV-2 genome/transcriptome. The majority of mapped mutations in SARS-CoV-2 genome are A-to-G/U-to-C(opposite strand) and C-to-U/G-to-A(opposite strand) substitutions comprising potential ADAR-/APOBEC-mediated deamination events. A single nucleotide substitution can have dramatic effects on SARS-CoV-2 infectivity as shown by the D614G(A-to-G) substitution in the spike protein. Future studies utilizing serial sampling from patients with COVID-19 are warranted to delineate whether RNA editing affects viral replication and/or the host immune response to SARS-CoV-2. Twit Text FOAVip The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33639276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33639276 #FOAvip English Wikipedia <ref>{{Cite pmid|33639276}}</ref> The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection #MMPMID33639276 Vlachogiannis NI; Verrou KM; Stellos K; Sfikakis PP; Paraskevis D Clin Immunol 2021[May]; 226 (ä): 108699 PMID33639276show ga RNA editing is a fundamental biological process with 2 major forms, namely adenosine-to-inosine (A-to-I, recognized as A-to-G) and cytosine-to-uracil (C-to-U) deamination, mediated by ADAR and APOBEC enzyme families, respectively. A-to-I RNA editing has been shown to directly affect the genome/transcriptome of RNA viruses with significant repercussions for viral protein synthesis, proliferation and infectivity, while it also affects recognition of double-stranded RNAs by cytosolic receptors controlling the host innate immune response. Recent evidence suggests that RNA editing may be present in SARS-CoV-2 genome/transcriptome. The majority of mapped mutations in SARS-CoV-2 genome are A-to-G/U-to-C(opposite strand) and C-to-U/G-to-A(opposite strand) substitutions comprising potential ADAR-/APOBEC-mediated deamination events. A single nucleotide substitution can have dramatic effects on SARS-CoV-2 infectivity as shown by the D614G(A-to-G) substitution in the spike protein. Future studies utilizing serial sampling from patients with COVID-19 are warranted to delineate whether RNA editing affects viral replication and/or the host immune response to SARS-CoV-2. |*Immunity, Innate[MESH] |*RNA Editing[MESH] |APOBEC Deaminases/genetics/*metabolism[MESH] |Adenosine Deaminase/genetics/*metabolism[MESH] |COVID-19/enzymology/*immunology/virology[MESH] |Humans[MESH] |Mutation[MESH] |RNA Viruses/*genetics/pathogenicity[MESH] |RNA, Double-Stranded/metabolism[MESH] |RNA-Binding Proteins/genetics/*metabolism[MESH]The role of A-to-I RNA editing in infections by RNA viruses: Possible (epmc).pdf DeepDyve Pubget Overpricing