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10.1016/j.ejphar.2021.173977 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2021.173977 33639193!7905377!33639193     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2021 ; 898 (ä): 173977 Nephropedia Template TP {{tp|p=33639193|t=2021. Brief review on repurposed drugs and vaccines for possible treatment of COVID-19 |pdf=|usr=}}{{33639193}} gab.com Text Brief review on repurposed drugs and vaccines for possible treatment of COVID-19 JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33639193 #FOAvip Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral targets like proteases. We try to understand the molecular mechanism of various repurposed antiviral drugs against SARS-CoV-2, their combination therapies, drug dosage regimens, and their adverse effects along with possible alternatives like non-toxic antiviral phytochemicals. Ultimately, randomized controlled trials are needed to identify which of these compounds has the required balance of efficacy and safety. We also focus on the recent advancements in diagnostic methods and vaccine candidates developed around the world to fight against Covid-19. Twit Text FOAVip Brief review on repurposed drugs and vaccines for possible treatment of COVID-19 ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33639193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33639193 #FOAvip English Wikipedia <ref>{{Cite pmid|33639193}}</ref> Brief review on repurposed drugs and vaccines for possible treatment of COVID-19 #MMPMID33639193 De P; Chakraborty I; Karna B; Mazumder N Eur J Pharmacol 2021[May]; 898 (ä): 173977 PMID33639193show ga Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral targets like proteases. We try to understand the molecular mechanism of various repurposed antiviral drugs against SARS-CoV-2, their combination therapies, drug dosage regimens, and their adverse effects along with possible alternatives like non-toxic antiviral phytochemicals. Ultimately, randomized controlled trials are needed to identify which of these compounds has the required balance of efficacy and safety. We also focus on the recent advancements in diagnostic methods and vaccine candidates developed around the world to fight against Covid-19. |*COVID-19 Drug Treatment[MESH] |*COVID-19 Vaccines[MESH] |*SARS-CoV-2/immunology[MESH] |Antiviral Agents/*administration & dosage/adverse effects[MESH] |COVID-19 Testing[MESH] |COVID-19/diagnosis/prevention & control[MESH] |Drug Repositioning[MESH] |Humans[MESH]Brief review on repurposed drugs and vaccines for possible treatment o(epmc).pdf DeepDyve Pubget Overpricing