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10.1016/j.cca.2021.02.011 http://scihub22266oqcxt.onion/10.1016/j.cca.2021.02.011 33639119!7903909!33639119     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chim+Acta 2021 ; 517 (ä): 66-73 Nephropedia Template TP {{tp|p=33639119|t=2021. Lipid metabolism changes in patients with severe COVID-19 |pdf=|usr=}}{{33639119}} gab.com Text Lipid metabolism changes in patients with severe COVID-19 JO: Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=33639119 #FOAvip BACKGROUND: We investigated the dynamic changes in lipid profiles and their correlations with disease severity and clinical outcome in patients with severe COVID-19. METHODS: We retrospectively reviewed 519 severe COVID-19 patients with confirmed outcomes (discharged or deceased), admitted to the West Court of Union Hospital in Wuhan, China, between 29 January and 8 April 2020. RESULTS: Altogether, 424 severe COVID-19 patients, including 34 non-survivors and 390 survivors, were included in the final analyses. During hospitalization, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) showed an increasing trend in survivors, but showed a downward trend in non-survivors. The serum concentrations of HDL-C and apoA-I were inversely correlated with C-reactive protein (CRP), length of hospital stay of survivors, and disease severity scores. For in-hospital deaths, the areas under the receiver operating characteristic curves (AUCs) of the ratios of CRP/HDL-C and CRP/apoA-I at admission were 0.84 and 0.83, respectively. Moreover, patients with high ratios of CRP/HDL-C (?77.39) or CRP/apoA-I (?72.37) had higher mortality rates during hospitalization (log-rank p < 0.001). Logistic regression analysis demonstrated that hypertension, lactate dehydrogenase, SOFA score, and High CRP/HDL-C ratio were independent predictors of in-hospital mortality. CONCLUSIONS: During severe COVID-19, HDL-C and apoA-I concentrations are dramatically decreased in non-survivors. Moreover, High CRP/HDL-C ratio is significantly associated with an increase in mortality and a poor prognosis. Twit Text FOAVip Lipid metabolism changes in patients with severe COVID-19 ????Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=33639119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33639119 #FOAvip English Wikipedia <ref>{{Cite pmid|33639119}}</ref> Lipid metabolism changes in patients with severe COVID-19 #MMPMID33639119 Li Y; Zhang Y; Lu R; Dai M; Shen M; Zhang J; Cui Y; Liu B; Lin F; Chen L; Han D; Fan Y; Zeng Y; Li W; Li S; Chen X; Li H; Pan P Clin Chim Acta 2021[Jun]; 517 (ä): 66-73 PMID33639119show ga BACKGROUND: We investigated the dynamic changes in lipid profiles and their correlations with disease severity and clinical outcome in patients with severe COVID-19. METHODS: We retrospectively reviewed 519 severe COVID-19 patients with confirmed outcomes (discharged or deceased), admitted to the West Court of Union Hospital in Wuhan, China, between 29 January and 8 April 2020. RESULTS: Altogether, 424 severe COVID-19 patients, including 34 non-survivors and 390 survivors, were included in the final analyses. During hospitalization, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) showed an increasing trend in survivors, but showed a downward trend in non-survivors. The serum concentrations of HDL-C and apoA-I were inversely correlated with C-reactive protein (CRP), length of hospital stay of survivors, and disease severity scores. For in-hospital deaths, the areas under the receiver operating characteristic curves (AUCs) of the ratios of CRP/HDL-C and CRP/apoA-I at admission were 0.84 and 0.83, respectively. Moreover, patients with high ratios of CRP/HDL-C (?77.39) or CRP/apoA-I (?72.37) had higher mortality rates during hospitalization (log-rank p < 0.001). Logistic regression analysis demonstrated that hypertension, lactate dehydrogenase, SOFA score, and High CRP/HDL-C ratio were independent predictors of in-hospital mortality. CONCLUSIONS: During severe COVID-19, HDL-C and apoA-I concentrations are dramatically decreased in non-survivors. Moreover, High CRP/HDL-C ratio is significantly associated with an increase in mortality and a poor prognosis. |*COVID-19/blood/mortality/physiopathology[MESH] |*Lipid Metabolism[MESH] |Aged[MESH] |Apolipoprotein A-I/blood[MESH] |C-Reactive Protein/analysis[MESH] |China[MESH] |Cholesterol, HDL/blood[MESH] |Cholesterol, LDL/blood[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Lipid metabolism changes in patients with severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing