Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/jmv.26911 http://scihub22266oqcxt.onion/10.1002/jmv.26911 33638460!8014076!33638460     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (7): 4205-4218 Nephropedia Template TP {{tp|p=33638460|t=2021. Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 |pdf=|usr=}}{{33638460}} gab.com Text Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33638460 #FOAvip Epidemiological data shows a discrepancy in COVID-19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of the host cell to SARS-CoV-2. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by the TMPRSS2 gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review, we have investigated the pathogenicity of SARS-CoV-2 and disease susceptibility dependence on the TMPRSS2 gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS-CoV-2 infection and Coronavirus disease (COVID)-19 outcomes. Moreover, promising new TMPRSS2 protease blockers and inhibitors are discussed for COVID-19 treatment. Twit Text FOAVip Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33638460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33638460 #FOAvip English Wikipedia <ref>{{Cite pmid|33638460}}</ref> Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 #MMPMID33638460 Abbasi AZ; Kiyani DA; Hamid SM; Saalim M; Fahim A; Jalal N J Med Virol 2021[Jul]; 93 (7): 4205-4218 PMID33638460show ga Epidemiological data shows a discrepancy in COVID-19 susceptibility and outcomes with some regions being more heavily affected than others. However, the factors that determine host susceptibility and pathogenicity remain elusive. An increasing number of publications highlight the role of Transmembrane Serine Protease 2 (TMPRSS2) in the susceptibility of the host cell to SARS-CoV-2. Cleavage of viral spike protein via the host cell's TMPRSS2 enzyme activity mediates viral entry into the host cell. The enzyme synthesis is regulated by the TMPRSS2 gene, which has also been implicated in the entry mechanisms of previously reported Coronavirus infections. In this review, we have investigated the pathogenicity of SARS-CoV-2 and disease susceptibility dependence on the TMPRSS2 gene as expressed in various population groups. We further discuss how the differential expression of this gene in various ethnic groups can affect the SARS-CoV-2 infection and Coronavirus disease (COVID)-19 outcomes. Moreover, promising new TMPRSS2 protease blockers and inhibitors are discussed for COVID-19 treatment. |*COVID-19 Drug Treatment[MESH] |Anosmia/pathology[MESH] |COVID-19/pathology[MESH] |Female[MESH] |Genetic Predisposition to Disease/genetics[MESH] |Humans[MESH] |Male[MESH] |SARS-CoV-2/drug effects[MESH] |Serine Endopeptidases/*drug effects/genetics/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2 (epmc).pdf DeepDyve Pubget Overpricing