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10.1038/s41366-021-00776-8 http://scihub22266oqcxt.onion/10.1038/s41366-021-00776-8 33637951!7909378!33637951     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33637951&cmd=llinks): Failed to open stream: HTTP request failed! 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Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis |pdf=|usr=}}{{33637951}} gab.com Text Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis JO: Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33637951 #FOAvip BACKGROUND: Recent studies have shown that obesity is associated with the severity of coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms. MATERIALS AND METHODS: The electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched and all studies conducted on COVID-19 and obesity were reviewed. All studies were independently screened by reviewers based on their titles and abstracts. RESULTS: Forty relevant articles were selected, and their full texts were reviewed. Obesity affects the respiratory and immune systems through various mechanisms. Cytokine and adipokine secretion from adipose tissue leads to a pro-inflammatory state in obese patients, predisposing them to thrombosis, incoordination of innate and adaptive immune responses, inadequate antibody response, and cytokine storm. Obese patients had a longer virus shedding. Obesity is associated with other comorbidities such as hypertension, cardiovascular diseases, diabetes mellitus, and vitamin D deficiency. Hospitalization, intensive care unit admission, mechanical ventilation, and even mortality in obese patients were higher than normal-weight patients. Obesity could alter the direction of severe COVID-19 symptoms to younger individuals. Reduced physical activity, unhealthy eating habits and, more stress and fear experienced during the COVID-19 pandemic may result in more weight gain and obesity. CONCLUSIONS: Obesity should be considered as an independent risk factor for the severity of COVID-19. Paying more attention to preventing weight gain in obese patients with COVID-19 infection in early levels of disease is crucial during this pandemic. Twit Text FOAVip Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis ????Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33637951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33637951 #FOAvip English Wikipedia <ref>{{Cite pmid|33637951}}</ref> Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis #MMPMID33637951 Aghili SMM; Ebrahimpur M; Arjmand B; Shadman Z; Pejman Sani M; Qorbani M; Larijani B; Payab M Int J Obes (Lond) 2021[May]; 45 (5): 998-1016 PMID33637951show ga BACKGROUND: Recent studies have shown that obesity is associated with the severity of coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms. MATERIALS AND METHODS: The electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched and all studies conducted on COVID-19 and obesity were reviewed. All studies were independently screened by reviewers based on their titles and abstracts. RESULTS: Forty relevant articles were selected, and their full texts were reviewed. Obesity affects the respiratory and immune systems through various mechanisms. Cytokine and adipokine secretion from adipose tissue leads to a pro-inflammatory state in obese patients, predisposing them to thrombosis, incoordination of innate and adaptive immune responses, inadequate antibody response, and cytokine storm. Obese patients had a longer virus shedding. Obesity is associated with other comorbidities such as hypertension, cardiovascular diseases, diabetes mellitus, and vitamin D deficiency. Hospitalization, intensive care unit admission, mechanical ventilation, and even mortality in obese patients were higher than normal-weight patients. Obesity could alter the direction of severe COVID-19 symptoms to younger individuals. Reduced physical activity, unhealthy eating habits and, more stress and fear experienced during the COVID-19 pandemic may result in more weight gain and obesity. CONCLUSIONS: Obesity should be considered as an independent risk factor for the severity of COVID-19. Paying more attention to preventing weight gain in obese patients with COVID-19 infection in early levels of disease is crucial during this pandemic. |*COVID-19[MESH] |*Obesity[MESH] |Adipokines/metabolism[MESH] |Adipose Tissue/immunology/metabolism[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Comorbidity[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Humans[MESH] |Inflammation[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |SARS-CoV-2[MESH]Obesity in COVID-19 era, implications for mechanisms, comorbidities, a(epmc).pdf DeepDyve Pubget Overpricing