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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 An+Pediatr+(Engl+Ed) 2021 ; 97 (1): 22-9 Nephropedia Template TP
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Repercusion del confinamiento por COVID-19 sobre el control glucemico en ninos y adolescentes con diabetes mellitus tipo 1 #MMPMID33637472
Sanchez Conejero M; Gonzalez de Buitrago Amigo J; Tejado Bravo ML; de Nicolas Jimenez JM
An Pediatr (Engl Ed) 2021[Jan]; 97 (1): 22-9 PMID33637472show ga
BACKGROUND AND AIMS: To face the rapid spread of SARS-CoV-2 coronavirus pandemic, home lockdown in Spain was decreed on 15th March 2020. The main objective of this study is to evaluate the impact of this constraint on glycemic control in children and adolescents with type 1 diabetes mellitus (T1D). PATIENTS AND METHODS: Observational, retrospective study in children and adolescents with T1D users of interstitial glucose monitoring systems. The following information corresponding to the last 2 weeks of lockdown was collected for subsequent comparison with data of 2 weeks prior to quarantine: daily insulin needs, mean interstitial glucose, estimated HbA1c, coefficient of variation (CV), time in range (70-180mg/dl), hypoglycemia (<70 and <54mg/dl), and hyperglycemia (>180 and>250mg/dl), sensor use and number of blood glucose measurements. Data about meal routines, physical exercise, need for adjustments in therapy, acute complications, and lockdown of caregivers were assessed via a survey. RESULTS: 80 patients were studied (mean age 12.61+/-3.32 years, mean time of evolution of the disease 5.85+/-3.92 years), 66.2% treated with an insulin pump, users of following glucose monitoring systems: Guardian(TM) 3 (65%), FreeStyle Libre(TM) (18.8%) and Dexcom G6(TM) (16.2%). Time in range in the cohort increased significantly during confinement (72.1+/-10.5 vs. 74.8+/-10.5%; P=.011) with lower time in hypoglycemia both<70mg/dl (4.6+/-3.2 vs. 3.2+/-2.7%; P<.001) and<54mg/dl (1.2+/-1.6 vs. 0.7+/-1.2%; p<0.001) and hyperglycemia >250mg/dl (4.6+/-3.9 vs. 3.7+/-3.7%; P=.038). CV also decreased (35.8+/-6.3 vs. 33.1+/-6.1%; P<.001). Patients treated with multiple doses of insulin and poorer baseline glycemic control experienced greatest improvement. Daily insulin requirements remained stable. Regular practice of physical exercise and caregivers' confinement did not have a significant impact. CONCLUSIONS: Glycemic control in children and adolescents with T1D improved during quarantine, particularly in those with worse baseline control.