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10.1016/j.ijid.2021.02.085

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.02.085
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33636357!7901274!33636357
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suck abstract from ncbi


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pmid33636357      Int+J+Infect+Dis 2021 ; 105 (ä): 304-306
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  • Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1) #MMPMID33636357
  • Dugas M; Grote-Westrick T; Vollenberg R; Lorentzen E; Brix T; Schmidt H; Tepasse PR; Kuhn J
  • Int J Infect Dis 2021[Apr]; 105 (ä): 304-306 PMID33636357show ga
  • The clinical course of COVID-19 is very heterogeneous: most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We performed a biomarker study to assess the impact of prior infections with seasonal coronaviruses on COVID-19 severity. Sixty patients with confirmed COVID-19 infections were included (age 30-82; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease, and 25 outpatients. Patients with critical disease had significantly lower levels of anti-HCoV OC43-NP (P = 0.016) and HCoV HKU1-NP (P = 0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that prior infections with seasonal coronaviruses might protect against a severe course of disease.
  • |*Antibodies, Viral[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*immunology[MESH]
  • |Coronavirus Infections/immunology[MESH]
  • |Coronavirus OC43, Human/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Seasons[MESH]


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