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10.1016/j.lfs.2021.119251 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119251 33636175!7900755!33636175     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 272 (ä): 119251 Nephropedia Template TP {{tp|p=33636175|t=2021. Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives |pdf=|usr=}}{{33636175}} gab.com Text Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33636175 #FOAvip A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients. The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, has important roles in pulmonary pathological states, including fibrosis, pneumonia and ARDS. RAGE overexpression/hyperactivation is essential to the deleterious effects of RAS in several pathological processes, including hypertension, chronic kidney and cardiovascular diseases, and diabetes, all of which are major comorbidities of SARS-CoV-2 infection. We propose RAGE as an additional molecular target in COVID-19 patients for ameliorating the multi-organ pathology induced by the virus and improving survival, also in the perspective of future infections by other coronaviruses. Twit Text FOAVip Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33636175 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33636175 #FOAvip English Wikipedia <ref>{{Cite pmid|33636175}}</ref> Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives #MMPMID33636175 Chiappalupi S; Salvadori L; Vukasinovic A; Donato R; Sorci G; Riuzzi F Life Sci 2021[May]; 272 (ä): 119251 PMID33636175show ga A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients. The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, has important roles in pulmonary pathological states, including fibrosis, pneumonia and ARDS. RAGE overexpression/hyperactivation is essential to the deleterious effects of RAS in several pathological processes, including hypertension, chronic kidney and cardiovascular diseases, and diabetes, all of which are major comorbidities of SARS-CoV-2 infection. We propose RAGE as an additional molecular target in COVID-19 patients for ameliorating the multi-organ pathology induced by the virus and improving survival, also in the perspective of future infections by other coronaviruses. |*Drug Discovery[MESH] |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*complications/metabolism/pathology[MESH] |Humans[MESH] |Molecular Targeted Therapy[MESH] |Multiple Organ Failure/*etiology/metabolism/pathology/*prevention & control[MESH] |Receptor for Advanced Glycation End Products/*antagonists & inhibitors/metabolism[MESH] |Renin-Angiotensin System/drug effects[MESH] |SARS-CoV-2/drug effects/*physiology[MESH]Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: (epmc).pdf DeepDyve Pubget Overpricing