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10.1371/journal.ppat.1009352 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009352 33635919!8130932!33635919     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33635919&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (2): e1009352 Nephropedia Template TP {{tp|p=33635919|t=2021. Breadth and function of antibody response to acute SARS-CoV-2 infection in humans |pdf=|usr=}}{{33635919}} gab.com Text Breadth and function of antibody response to acute SARS-CoV-2 infection in humans JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33635919 #FOAvip Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different clinical severities. Potent humoral responses were detected within 3 weeks of onset of illness in all patients and the serological titre was elicited soon after or concomitantly with peripheral plasmablast response. An average of 13.7% and 3.5% of plasmablast-derived MAbs were reactive with virus spike glycoprotein or nucleocapsid, respectively. A subset of anti-spike (10 of 32) antibodies cross-reacted with other betacoronaviruses tested and harboured extensive somatic mutations, indicative of an expansion of memory B cells upon SARS-CoV-2 infection. Fourteen of 32 anti-spike MAbs, including five anti-receptor-binding domain (RBD), three anti-non-RBD S1 and six anti-S2, neutralised wild-type SARS-CoV-2 in independent assays. Anti-RBD MAbs were further grouped into four cross-inhibiting clusters, of which six antibodies from three separate clusters blocked the binding of RBD to ACE2 and five were neutralising. All ACE2-blocking anti-RBD antibodies were isolated from two recovered patients with prolonged fever, which is compatible with substantial ACE2-blocking response in their sera. Finally, the identification of non-competing pairs of neutralising antibodies would offer potential templates for the development of prophylactic and therapeutic agents against SARS-CoV-2. Twit Text FOAVip Breadth and function of antibody response to acute SARS-CoV-2 infection in humans ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33635919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33635919 #FOAvip English Wikipedia <ref>{{Cite pmid|33635919}}</ref> Breadth and function of antibody response to acute SARS-CoV-2 infection in humans #MMPMID33635919 Huang KA; Tan TK; Chen TH; Huang CG; Harvey R; Hussain S; Chen CP; Harding A; Gilbert-Jaramillo J; Liu X; Knight M; Schimanski L; Shih SR; Lin YC; Cheng CY; Cheng SH; Huang YC; Lin TY; Jan JT; Ma C; James W; Daniels RS; McCauley JW; Rijal P; Townsend AR PLoS Pathog 2021[Feb]; 17 (2): e1009352 PMID33635919show ga Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different clinical severities. Potent humoral responses were detected within 3 weeks of onset of illness in all patients and the serological titre was elicited soon after or concomitantly with peripheral plasmablast response. An average of 13.7% and 3.5% of plasmablast-derived MAbs were reactive with virus spike glycoprotein or nucleocapsid, respectively. A subset of anti-spike (10 of 32) antibodies cross-reacted with other betacoronaviruses tested and harboured extensive somatic mutations, indicative of an expansion of memory B cells upon SARS-CoV-2 infection. Fourteen of 32 anti-spike MAbs, including five anti-receptor-binding domain (RBD), three anti-non-RBD S1 and six anti-S2, neutralised wild-type SARS-CoV-2 in independent assays. Anti-RBD MAbs were further grouped into four cross-inhibiting clusters, of which six antibodies from three separate clusters blocked the binding of RBD to ACE2 and five were neutralising. All ACE2-blocking anti-RBD antibodies were isolated from two recovered patients with prolonged fever, which is compatible with substantial ACE2-blocking response in their sera. Finally, the identification of non-competing pairs of neutralising antibodies would offer potential templates for the development of prophylactic and therapeutic agents against SARS-CoV-2. |Adult[MESH] |Angiotensin-Converting Enzyme 2/antagonists & inhibitors/immunology[MESH] |Antibodies, Monoclonal/immunology[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/blood/genetics/*immunology[MESH] |Antibody-Producing Cells/immunology[MESH] |Binding Sites[MESH] |COVID-19/*immunology[MESH] |Epitopes[MESH] |Humans[MESH] |Immunoglobulin G/immunology[MESH] |Nucleocapsid/immunology[MESH] |SARS-CoV-2/*immunology[MESH]Breadth and function of antibody response to acute SARS-CoV-2 infectio(epmc).pdf DeepDyve Pubget Overpricing