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10.1172/JCI145853 http://scihub22266oqcxt.onion/10.1172/JCI145853 33635833!8262478!33635833     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (8): ä Nephropedia Template TP {{tp|p=33635833|t=2021. Identification of SARS-CoV-2-specific immune alterations in acutely ill patients |pdf=|usr=}}{{33635833}} gab.com Text Identification of SARS-CoV-2-specific immune alterations in acutely ill patients JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33635833 #FOAvip Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of (a) patients hospitalized with acute SARS-CoV-2 infection, (b) patients of comparable age and sex hospitalized for another acute disease (SARS-CoV-2 negative), and (c) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g., decreased proportion of T cells) that were similarly associated with acute SARS-CoV-2 infection and non-COVID-19-related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that were associated with SARS-CoV-2 status (e.g., elevated proportion of ICAM-1+ mature/activated neutrophils, ALCAM+ monocytes, and CD38+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality. Our data provide an understanding of the immune dysregulation specifically associated with SARS-CoV-2 infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2-positive patients at risk of unfavorable outcomes and to uncover candidate molecules to investigate from a therapeutic perspective. Twit Text FOAVip Identification of SARS-CoV-2-specific immune alterations in acutely ill patients ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33635833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33635833 #FOAvip English Wikipedia <ref>{{Cite pmid|33635833}}</ref> Identification of SARS-CoV-2-specific immune alterations in acutely ill patients #MMPMID33635833 Rebillard RM; Charabati M; Grasmuck C; Filali-Mouhim A; Tastet O; Brassard N; Daigneault A; Bourbonniere L; Anand SP; Balthazard R; Beaudoin-Bussieres G; Gasser R; Benlarbi M; Moratalla AC; Solorio YC; Boutin M; Farzam-Kia N; Descoteaux-Dinelle J; Fournier AP; Gowing E; Laumaea A; Jamann H; Lahav B; Goyette G; Lemaitre F; Mamane VH; Prevost J; Richard J; Thai K; Cailhier JF; Chomont N; Finzi A; Chasse M; Durand M; Arbour N; Kaufmann DE; Prat A; Larochelle C J Clin Invest 2021[Apr]; 131 (8): ä PMID33635833show ga Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of (a) patients hospitalized with acute SARS-CoV-2 infection, (b) patients of comparable age and sex hospitalized for another acute disease (SARS-CoV-2 negative), and (c) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g., decreased proportion of T cells) that were similarly associated with acute SARS-CoV-2 infection and non-COVID-19-related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that were associated with SARS-CoV-2 status (e.g., elevated proportion of ICAM-1+ mature/activated neutrophils, ALCAM+ monocytes, and CD38+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality. Our data provide an understanding of the immune dysregulation specifically associated with SARS-CoV-2 infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2-positive patients at risk of unfavorable outcomes and to uncover candidate molecules to investigate from a therapeutic perspective. |*SARS-CoV-2/immunology[MESH] |Acute Disease[MESH] |Adult[MESH] |Aged[MESH] |B-Lymphocyte Subsets/immunology[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19/epidemiology/*immunology/mortality[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Leukocytes/*classification/*immunology[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Models, Immunological[MESH] |Monocytes/immunology[MESH] |Multivariate Analysis[MESH] |Neutrophils/immunology[MESH] |Pandemics[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |Quebec/epidemiology[MESH] |Risk Factors[MESH]Identification of SARS-CoV-2-specific immune alterations in acutely il(epmc).pdf DeepDyve Pubget Overpricing