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10.1111/andr.12993 http://scihub22266oqcxt.onion/10.1111/andr.12993 33635589!8013327!33635589     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Andrology 2021 ; 9 (4): 1043-1052 Nephropedia Template TP {{tp|p=33635589|t=2021. Severely low testosterone in males with COVID-19: A case-control study |pdf=|usr=}}{{33635589}} gab.com Text Severely low testosterone in males with COVID-19: A case-control study JO: Andrology http://www.kidney.de/pget.php?&tw=1&pmid=33635589 #FOAvip BACKGROUND: Circulating androgens could have a relevant pathobiological role in clinical outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19). OBJECTIVES: We aimed to assess: (a) circulating sex steroids levels in a cohort of 286 symptomatic men with laboratory-confirmed COVID-19 at hospital admission compared to a cohort of 281 healthy men; and (b) the association between serum testosterone levels (tT), COVID-19, and clinical outcomes. MATERIALS AND METHODS: Demographic, clinical, and hormonal values were collected for all patients. Hypogonadism was defined as tT </=9.2 nmol/l. The Charlson Comorbidity Index (CCI) was used to score health-significant comorbidities. Severe clinical outcomes were defined as patients either transferred to intensive care unit (ICU) or death. Descriptive statistics and multivariable linear and logistic regression models tested the association between clinical and laboratory variables and tT levels. Univariable and multivariable logistic regression models tested the association between tT and severe clinical outcomes. RESULTS: Overall, a significantly lower levels of LH and tT were found in patients with COVID-19 compared to healthy controls (all p < 0.0001); conversely, healthy controls depicted lower values of circulating E(2) (p < 0.001). Testosterone levels suggestive for hypogonadism were observed in 257 (89.8%) patients at hospital admission. In as many as 243 (85%) cases, hypogonadism was secondary. SARS-CoV-2 infection status was independently associated with lower tT levels (p < 0.0001) and greater risk of hypogonadism (p < 0.0001), after accounting for age, BMI, CCI, and IL-6 values. Lower tT levels were associated with higher risk of ICU admission and death outcomes (all p </= 0.05), after accounting for clinical and laboratory parameters. CONCLUSIONS: We unveil an independent association between SARS-CoV-2 infection status and secondary hypogonadism already at hospital admission, with lower testosterone levels predicting the most severe clinical outcomes. Twit Text FOAVip Severely low testosterone in males with COVID-19: A case-control study ????Andrology http://www.kidney.de/pget.php?&tw=1&pmid=33635589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33635589 #FOAvip English Wikipedia <ref>{{Cite pmid|33635589}}</ref> Severely low testosterone in males with COVID-19: A case-control study #MMPMID33635589 Salonia A; Pontillo M; Capogrosso P; Gregori S; Tassara M; Boeri L; Carenzi C; Abbate C; Cignoli D; Ferrara AM; Cazzaniga W; Rowe I; Ramirez GA; Tresoldi C; Mushtaq J; Locatelli M; Santoleri L; Castagna A; Zangrillo A; De Cobelli F; Tresoldi M; Landoni G; Rovere-Querini P; Ciceri F; Montorsi F Andrology 2021[Jul]; 9 (4): 1043-1052 PMID33635589show ga BACKGROUND: Circulating androgens could have a relevant pathobiological role in clinical outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19). OBJECTIVES: We aimed to assess: (a) circulating sex steroids levels in a cohort of 286 symptomatic men with laboratory-confirmed COVID-19 at hospital admission compared to a cohort of 281 healthy men; and (b) the association between serum testosterone levels (tT), COVID-19, and clinical outcomes. MATERIALS AND METHODS: Demographic, clinical, and hormonal values were collected for all patients. Hypogonadism was defined as tT |Adult[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |COVID-19/*blood/complications[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Gonadal Steroid Hormones/blood[MESH] |Humans[MESH] |Hypogonadism/blood/etiology[MESH] |Male[MESH] |Middle Aged[MESH] |Testosterone/*blood[MESH]Severely low testosterone in males with COVID-19: A case-control study(epmc).pdf DeepDyve Pubget Overpricing