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10.1182/bloodadvances.2020003568 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2020003568 33635335!7908851!33635335     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Adv 2021 ; 5 (5): 1164-1177 Nephropedia Template TP {{tp|p=33635335|t=2021. A neutrophil activation signature predicts critical illness and mortality in COVID-19 |pdf=|usr=}}{{33635335}} gab.com Text A neutrophil activation signature predicts critical illness and mortality in COVID-19 JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=33635335 #FOAvip Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling of plasma from cross-sectional and longitudinal cohorts of hospitalized patients with COVID-19 and analyzed clinical data from our health system database of more than 3300 patients. Using a machine learning algorithm, we identified a prominent signature of neutrophil activation, including resistin, lipocalin-2, hepatocyte growth factor, interleukin-8, and granulocyte colony-stimulating factor, which were the strongest predictors of critical illness. Evidence of neutrophil activation was present on the first day of hospitalization in patients who would only later require transfer to the intensive care unit, thus preceding the onset of critical illness and predicting increased mortality. In the health system database, early elevations in developing and mature neutrophil counts also predicted higher mortality rates. Altogether, these data suggest a central role for neutrophil activation in the pathogenesis of severe COVID-19 and identify molecular markers that distinguish patients at risk of future clinical decompensation. Twit Text FOAVip A neutrophil activation signature predicts critical illness and mortality in COVID-19 ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=33635335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33635335 #FOAvip English Wikipedia <ref>{{Cite pmid|33635335}}</ref> A neutrophil activation signature predicts critical illness and mortality in COVID-19 #MMPMID33635335 Meizlish ML; Pine AB; Bishai JD; Goshua G; Nadelmann ER; Simonov M; Chang CH; Zhang H; Shallow M; Bahel P; Owusu K; Yamamoto Y; Arora T; Atri DS; Patel A; Gbyli R; Kwan J; Won CH; Dela Cruz C; Price C; Koff J; King BA; Rinder HM; Wilson FP; Hwa J; Halene S; Damsky W; van Dijk D; Lee AI; Chun HJ Blood Adv 2021[Mar]; 5 (5): 1164-1177 PMID33635335show ga Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling of plasma from cross-sectional and longitudinal cohorts of hospitalized patients with COVID-19 and analyzed clinical data from our health system database of more than 3300 patients. Using a machine learning algorithm, we identified a prominent signature of neutrophil activation, including resistin, lipocalin-2, hepatocyte growth factor, interleukin-8, and granulocyte colony-stimulating factor, which were the strongest predictors of critical illness. Evidence of neutrophil activation was present on the first day of hospitalization in patients who would only later require transfer to the intensive care unit, thus preceding the onset of critical illness and predicting increased mortality. In the health system database, early elevations in developing and mature neutrophil counts also predicted higher mortality rates. Altogether, these data suggest a central role for neutrophil activation in the pathogenesis of severe COVID-19 and identify molecular markers that distinguish patients at risk of future clinical decompensation. |*Neutrophil Activation[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19/blood/*immunology/mortality[MESH] |Critical Illness/epidemiology/mortality[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Machine Learning[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |SARS-CoV-2/immunology[MESH]A neutrophil activation signature predicts critical illness and mortal(epmc).pdf DeepDyve Pubget Overpricing