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10.3389/fphys.2021.627260 http://scihub22266oqcxt.onion/10.3389/fphys.2021.627260 33633588!7900431!33633588     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2021 ; 12 (ä): 627260 Nephropedia Template TP {{tp|p=33633588|t=2021. The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection |pdf=|usr=}}{{33633588}} gab.com Text The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33633588 #FOAvip The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences in response to viral diseases; morbidity and mortality are greater in men than women. We outline the mechanisms by which being female offers a degree of protection from COVID19, that persists even when confounders such as comorbidities are considered. The physiological and immunological mechanisms are fascinating and range from incomplete X chromosome inactivation of immune genes, a crucial role for angiotensin converting enzyme 2 (ACE2), and regulation of both immune activity and ACE2 by sex steroids. From this flows understanding of why lung and other organs are more susceptible to COVID19 damage in men, and how their distinct immunological landscapes need to be acknowledged to guide prognosis and treatment. Pregnancy, menopause, and hormone replacement therapy bring changed hormonal environments and the need for better stratification in COVID19 studies. We end by noting clinical trials based on increasing estrogens or progesterone or anti-testosterone drugs; excellent examples of translational physiology. Twit Text FOAVip The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33633588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33633588 #FOAvip English Wikipedia <ref>{{Cite pmid|33633588}}</ref> The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection #MMPMID33633588 Wray S; Arrowsmith S Front Physiol 2021[]; 12 (ä): 627260 PMID33633588show ga The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences in response to viral diseases; morbidity and mortality are greater in men than women. We outline the mechanisms by which being female offers a degree of protection from COVID19, that persists even when confounders such as comorbidities are considered. The physiological and immunological mechanisms are fascinating and range from incomplete X chromosome inactivation of immune genes, a crucial role for angiotensin converting enzyme 2 (ACE2), and regulation of both immune activity and ACE2 by sex steroids. From this flows understanding of why lung and other organs are more susceptible to COVID19 damage in men, and how their distinct immunological landscapes need to be acknowledged to guide prognosis and treatment. Pregnancy, menopause, and hormone replacement therapy bring changed hormonal environments and the need for better stratification in COVID19 studies. We end by noting clinical trials based on increasing estrogens or progesterone or anti-testosterone drugs; excellent examples of translational physiology. äThe Physiological Mechanisms of the Sex-Based Difference in Outcomes o(epmc).pdf DeepDyve Pubget Overpricing