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10.1038/s41598-021-84053-8 http://scihub22266oqcxt.onion/10.1038/s41598-021-84053-8 33633229!7907372!33633229     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 4659 Nephropedia Template TP {{tp|p=33633229|t=2021. Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population |pdf=|usr=}}{{33633229}} gab.com Text Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33633229 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus responsible for coronavirus disease 2019 (COVID-19); it become a pandemic since March 2020. To date, there have been described three lineages of SARS-CoV-2 circulating worldwide, two of them are found among Mexican population, within these, we observed three mutations of spike (S) protein located at amino acids H49Y, D614G, and T573I. To understand if these mutations could affect the structural behavior of S protein of SARS-CoV-2, as well as the binding with S protein inhibitors (cepharanthine, nelfinavir, and hydroxychloroquine), molecular dynamic simulations and molecular docking were employed. It was found that these punctual mutations affect considerably the structural behavior of the S protein compared to wild type, which also affect the binding of its inhibitors into their respective binding site. Thus, further experimental studies are needed to explore if these affectations have an impact on drug-S protein binding and its possible clinical effect. Twit Text FOAVip Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33633229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33633229 #FOAvip English Wikipedia <ref>{{Cite pmid|33633229}}</ref> Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population #MMPMID33633229 Sixto-Lopez Y; Correa-Basurto J; Bello M; Landeros-Rivera B; Garzon-Tiznado JA; Montano S Sci Rep 2021[Feb]; 11 (1): 4659 PMID33633229show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus responsible for coronavirus disease 2019 (COVID-19); it become a pandemic since March 2020. To date, there have been described three lineages of SARS-CoV-2 circulating worldwide, two of them are found among Mexican population, within these, we observed three mutations of spike (S) protein located at amino acids H49Y, D614G, and T573I. To understand if these mutations could affect the structural behavior of S protein of SARS-CoV-2, as well as the binding with S protein inhibitors (cepharanthine, nelfinavir, and hydroxychloroquine), molecular dynamic simulations and molecular docking were employed. It was found that these punctual mutations affect considerably the structural behavior of the S protein compared to wild type, which also affect the binding of its inhibitors into their respective binding site. Thus, further experimental studies are needed to explore if these affectations have an impact on drug-S protein binding and its possible clinical effect. |*Point Mutation[MESH] |Amino Acid Sequence[MESH] |COVID-19/epidemiology/*virology[MESH] |Drug Discovery[MESH] |Humans[MESH] |Ligands[MESH] |Mexico/epidemiology[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Protein Conformation[MESH] |SARS-CoV-2/chemistry/*genetics[MESH] |Sequence Alignment[MESH]Structural insights into SARS-CoV-2 spike protein and its natural muta(epmc).pdf DeepDyve Pubget Overpricing