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10.1038/s41598-021-83366-y http://scihub22266oqcxt.onion/10.1038/s41598-021-83366-y 33633121!7907391!33633121     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33633121&cmd=llinks): Failed to open stream: HTTP request failed! 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Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients |pdf=|usr=}}{{33633121}} gab.com Text Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33633121 #FOAvip Multiple studies have reported a doubling in risk of Coronavirus Disease-2019 (COVID-19) among cancer patients. Here, we examine the potential biological rationale behind this recurrent epidemiological observation. By leveraging large-scale genome-wide transcriptional data of normal and malignant tissues from adults and children, we found evidence of increased expression of SARS-CoV-2 viral entry genes in the cancer state, particularly in respiratory, gastrointestinal, and genitourinary tract tissues, with decreased expression in pediatric vs. adult samples. Additionally, by interrogating the temporal effects of radiotherapy on human peripheral blood mononuclear and mucosal cells, we observed important treatment-related alterations in host innate immunity, specifically type I interferon responses. Overall, cancers enhance expression of critical viral entry genes, and innate viral defenses can be dysregulated transiently during radiation treatments. These factors may contribute to the observed increased susceptibility to SARS-CoV-2 entry and severity of COVID-19 in cancer patients. Twit Text FOAVip Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33633121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33633121 #FOAvip English Wikipedia <ref>{{Cite pmid|33633121}}</ref> Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients #MMPMID33633121 Kwan JYY; Lin LT; Bell R; Bruce JP; Richardson C; Pugh TJ; Liu FF Sci Rep 2021[Feb]; 11 (1): 4533 PMID33633121show ga Multiple studies have reported a doubling in risk of Coronavirus Disease-2019 (COVID-19) among cancer patients. Here, we examine the potential biological rationale behind this recurrent epidemiological observation. By leveraging large-scale genome-wide transcriptional data of normal and malignant tissues from adults and children, we found evidence of increased expression of SARS-CoV-2 viral entry genes in the cancer state, particularly in respiratory, gastrointestinal, and genitourinary tract tissues, with decreased expression in pediatric vs. adult samples. Additionally, by interrogating the temporal effects of radiotherapy on human peripheral blood mononuclear and mucosal cells, we observed important treatment-related alterations in host innate immunity, specifically type I interferon responses. Overall, cancers enhance expression of critical viral entry genes, and innate viral defenses can be dysregulated transiently during radiation treatments. These factors may contribute to the observed increased susceptibility to SARS-CoV-2 entry and severity of COVID-19 in cancer patients. |*Immunity, Innate[MESH] |*Virus Internalization[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2/genetics/immunology[MESH] |COVID-19/*complications/genetics/immunology[MESH] |Cathepsin L/genetics/immunology[MESH] |Child[MESH] |Female[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Humans[MESH] |Male[MESH] |Neoplasms/*complications/genetics/immunology/radiotherapy[MESH] |SARS-CoV-2/*physiology[MESH] |Serine Endopeptidases/genetics/immunology[MESH]Elevation in viral entry genes and innate immunity compromise underlyi(epmc).pdf DeepDyve Pubget Overpricing