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10.1016/j.intimp.2021.107407 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107407 33631512!7826095!33631512     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 93 (ä): 107407 Nephropedia Template TP {{tp|p=33631512|t=2021. Serum cytokine levels of COVID-19 patients after 7 days of treatment with Favipiravir or Kaletra |pdf=|usr=}}{{33631512}} gab.com Text Serum cytokine levels of COVID-19 patients after 7 days of treatment with Favipiravir or Kaletra JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33631512 #FOAvip BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has infected 86,4 M patients and resulted in 1,86 M deaths worldwide. Severe COVID-19 patients have elevated blood levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor (TNF)alpha, IL-8 and interferon (IFN)gamma. OBJECTIVE: To investigate the effect of antiviral treatment serum cytokines in severe COVID-19 patients. METHODS: Blood was obtained from 29 patients (aged 32-79 yr) with laboratory-confirmed COVID-19 upon admission and 7 days after antiviral (Favipiravir or Lopinavir/Ritonavir) treatment. Patients also received standard supportive treatment in this retrospective observational study. Chest computed tomography (CT) scans were evaluated to investigate lung manifestations of COVID-19. Serum was also obtained and cytokines levels were evaluated. 19 age- and gender-matched healthy controls were studied. RESULTS: Anti-viral therapy significantly reduced CT scan scores and the elevated serum levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH). In contrast, serum levels of IL-6, IL-8 and IFNgamma were elevated at baseline in COVID-19 subjects compared to healthy subjects with IL-6 (p = 0.006) and IL-8 (p = 0.011) levels being further elevated after antiviral therapy. IL-1beta (p = 0.01) and TNFalpha (p = 0.069) levels were also enhanced after treatment but baseline levels were similar to those of healthy controls. These changes occurred irrespective of whether patients were admitted to the intensive care unit. CONCLUSION: Antiviral treatments did not suppress the inflammatory phase of COVID-19 after 7 days treatment although CT, CRP and LDH suggest a decline in lung inflammation. There was limited evidence for a viral-mediated cytokine storm in these COVID-19 subjects. Twit Text FOAVip Serum cytokine levels of COVID-19 patients after 7 days of treatment with Favipiravir or Kaletra ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33631512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33631512 #FOAvip English Wikipedia <ref>{{Cite pmid|33631512}}</ref> Serum cytokine levels of COVID-19 patients after 7 days of treatment with Favipiravir or Kaletra #MMPMID33631512 Mortaz E; Bassir A; Dalil Roofchayee N; Dezfuli NK; Jamaati H; Tabarsi P; Moniri A; Rezaei M; Mehrian P; Varahram M; Marjani M; Mumby S; Adcock IM Int Immunopharmacol 2021[Apr]; 93 (ä): 107407 PMID33631512show ga BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has infected 86,4 M patients and resulted in 1,86 M deaths worldwide. Severe COVID-19 patients have elevated blood levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor (TNF)alpha, IL-8 and interferon (IFN)gamma. OBJECTIVE: To investigate the effect of antiviral treatment serum cytokines in severe COVID-19 patients. METHODS: Blood was obtained from 29 patients (aged 32-79 yr) with laboratory-confirmed COVID-19 upon admission and 7 days after antiviral (Favipiravir or Lopinavir/Ritonavir) treatment. Patients also received standard supportive treatment in this retrospective observational study. Chest computed tomography (CT) scans were evaluated to investigate lung manifestations of COVID-19. Serum was also obtained and cytokines levels were evaluated. 19 age- and gender-matched healthy controls were studied. RESULTS: Anti-viral therapy significantly reduced CT scan scores and the elevated serum levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH). In contrast, serum levels of IL-6, IL-8 and IFNgamma were elevated at baseline in COVID-19 subjects compared to healthy subjects with IL-6 (p = 0.006) and IL-8 (p = 0.011) levels being further elevated after antiviral therapy. IL-1beta (p = 0.01) and TNFalpha (p = 0.069) levels were also enhanced after treatment but baseline levels were similar to those of healthy controls. These changes occurred irrespective of whether patients were admitted to the intensive care unit. CONCLUSION: Antiviral treatments did not suppress the inflammatory phase of COVID-19 after 7 days treatment although CT, CRP and LDH suggest a decline in lung inflammation. There was limited evidence for a viral-mediated cytokine storm in these COVID-19 subjects. |*COVID-19 Drug Treatment[MESH] |Adult[MESH] |Aged[MESH] |Amides/*therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19/*blood/immunology[MESH] |Cytokines/*blood[MESH] |Drug Combinations[MESH] |Female[MESH] |Humans[MESH] |Lopinavir/*therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Pyrazines/*therapeutic use[MESH] |Retrospective Studies[MESH] |Ritonavir/*therapeutic use[MESH]Serum cytokine levels of COVID-19 patients after 7 days of treatment w(epmc).pdf DeepDyve Pubget Overpricing