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10.1016/j.virusres.2021.198347 http://scihub22266oqcxt.onion/10.1016/j.virusres.2021.198347 33631219!7898966!33631219     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Res 2021 ; 299 (ä): 198347 Nephropedia Template TP {{tp|p=33631219|t=2021. Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets |pdf=|usr=}}{{33631219}} gab.com Text Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=33631219 #FOAvip BACKGROUND: There is a marked discrepancy between SARS-CoV-2 seroprevalence and COVID-19 cases and deaths in Africa. MAIN: SARS-CoV-2 stimulates humoral and cellular immunity systems, as well as mitogen-activated protein kinase (MAPK) and nuclear NF-kB signalling pathways, which regulate inflammatory gene expression and immune cell differentiation. The result is pro-inflammatory cytokines release, hyperinflammatory condition, and cytokine storm, which provoke severe lung alterations that can lead to multi-organ failure in COVID-19. Multiple genetic and immunologic factors may contribute to the severity of COVID-19 in African individuals when compared to the rest of the global population. In this article, the role of malaria, NF-kB and MAPK pathways, caspase-12 expression, high level of LAIR-1-containing antibodies, and differential glycophorins (GYPA/B) expression in COVID-19 are discussed. CONCLUSION: Understanding pathophysiological mechanisms can help identify target points for drugs and vaccines development against COVID-19. To our knowledge, this is the first study that explores this link and proposes a biological and molecular answer to the epidemiologic discrepancy in COVID-19 in Africa. Twit Text FOAVip Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=33631219 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33631219 #FOAvip English Wikipedia <ref>{{Cite pmid|33631219}}</ref> Protection against COVID-19 in African population: Immunology, genetics, and malaria clues for therapeutic targets #MMPMID33631219 Altable M; de la Serna JM Virus Res 2021[Jul]; 299 (ä): 198347 PMID33631219show ga BACKGROUND: There is a marked discrepancy between SARS-CoV-2 seroprevalence and COVID-19 cases and deaths in Africa. MAIN: SARS-CoV-2 stimulates humoral and cellular immunity systems, as well as mitogen-activated protein kinase (MAPK) and nuclear NF-kB signalling pathways, which regulate inflammatory gene expression and immune cell differentiation. The result is pro-inflammatory cytokines release, hyperinflammatory condition, and cytokine storm, which provoke severe lung alterations that can lead to multi-organ failure in COVID-19. Multiple genetic and immunologic factors may contribute to the severity of COVID-19 in African individuals when compared to the rest of the global population. In this article, the role of malaria, NF-kB and MAPK pathways, caspase-12 expression, high level of LAIR-1-containing antibodies, and differential glycophorins (GYPA/B) expression in COVID-19 are discussed. CONCLUSION: Understanding pathophysiological mechanisms can help identify target points for drugs and vaccines development against COVID-19. To our knowledge, this is the first study that explores this link and proposes a biological and molecular answer to the epidemiologic discrepancy in COVID-19 in Africa. |Africa/epidemiology[MESH] |COVID-19/epidemiology/ethnology/*genetics/*immunology[MESH] |Caspase 12/genetics/immunology[MESH] |Glycophorins/genetics/immunology[MESH] |Humans[MESH] |Malaria/epidemiology/ethnology/*genetics/*immunology[MESH] |NF-kappa B/immunology[MESH] |Receptors, Immunologic/genetics/immunology[MESH] |SARS-CoV-2/immunology[MESH]Protection against COVID-19 in African population: Immunology, genetic(epmc).pdf DeepDyve Pubget Overpricing