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10.1016/j.molcel.2021.01.035 http://scihub22266oqcxt.onion/10.1016/j.molcel.2021.01.035 33631104!7843106!33631104     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2021 ; 81 (7): 1548-1552.e4 Nephropedia Template TP {{tp|p=33631104|t=2021. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication |pdf=|usr=}}{{33631104}} gab.com Text Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33631104 #FOAvip Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-A-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of 3 copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporation of 3 bases following RMP, resulting in delayed chain termination, which can guide the rational design of improved antiviral drugs. Twit Text FOAVip Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=33631104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33631104 #FOAvip English Wikipedia <ref>{{Cite pmid|33631104}}</ref> Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication #MMPMID33631104 Bravo JPK; Dangerfield TL; Taylor DW; Johnson KA Mol Cell 2021[Apr]; 81 (7): 1548-1552.e4 PMID33631104show ga Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19. Here, we present a 3.9-A-resolution cryo-EM reconstruction of a remdesivir-stalled RNA-dependent RNA polymerase complex, revealing full incorporation of 3 copies of remdesivir monophosphate (RMP) and a partially incorporated fourth RMP in the active site. The structure reveals that RMP blocks RNA translocation after incorporation of 3 bases following RMP, resulting in delayed chain termination, which can guide the rational design of improved antiviral drugs. |*Virus Replication[MESH] |Adenosine Monophosphate/*analogs & derivatives/chemistry/therapeutic use[MESH] |Alanine/*analogs & derivatives/chemistry/therapeutic use[MESH] |Antiviral Agents/*chemistry/therapeutic use[MESH] |Catalytic Domain[MESH] |Humans[MESH] |RNA, Viral/*chemistry[MESH] |RNA-Dependent RNA Polymerase/*chemistry[MESH] |SARS-CoV-2/*physiology[MESH]Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replicat(epmc).pdf DeepDyve Pubget Overpricing