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10.1172/JCI147329 http://scihub22266oqcxt.onion/10.1172/JCI147329 33630760!8262559!33630760     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (8): ä Nephropedia Template TP {{tp|p=33630760|t=2021. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations |pdf=|usr=}}{{33630760}} gab.com Text Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33630760 #FOAvip BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China. Twit Text FOAVip Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33630760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33630760 #FOAvip English Wikipedia <ref>{{Cite pmid|33630760}}</ref> Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations #MMPMID33630760 Qin Y; Wu J; Chen T; Li J; Zhang G; Wu D; Zhou Y; Zheng N; Cai A; Ning Q; Manyande A; Xu F; Wang J; Zhu W J Clin Invest 2021[Apr]; 131 (8): ä PMID33630760show ga BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China. |*SARS-CoV-2[MESH] |Aged[MESH] |Brain/blood supply/diagnostic imaging/pathology[MESH] |C-Reactive Protein/metabolism[MESH] |COVID-19/*diagnostic imaging/epidemiology/physiopathology[MESH] |Case-Control Studies[MESH] |Cerebrovascular Circulation/*physiology[MESH] |China/epidemiology[MESH] |Diffusion Tensor Imaging[MESH] |Echo-Planar Imaging[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Gray Matter/diagnostic imaging/pathology[MESH] |Humans[MESH] |Imaging, Three-Dimensional[MESH] |Inflammation Mediators/blood[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Neuroimaging[MESH] |Pandemics[MESH] |Procalcitonin/blood[MESH] |Severity of Illness Index[MESH] |Time Factors[MESH]Long-term microstructure and cerebral blood flow changes in patients r(epmc).pdf DeepDyve Pubget Overpricing