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10.1097/MCP.0000000000000775 http://scihub22266oqcxt.onion/10.1097/MCP.0000000000000775 33629970!ä!33629970 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Pulm+Med 2021 ; 27 (3): 193-198 Nephropedia Template TP {{tp|p=33629970|t=2021. COVID-19 - pathogenesis and immunological findings across the clinical manifestation spectrum |pdf=|usr=}}{{33629970}} gab.com Text COVID-19 - pathogenesis and immunological findings across the clinical manifestation spectrum JO: Curr Opin Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=33629970 #FOAvip PURPOSE OF REVIEW: The wide spectrum of COVID-19 clinical manifestations demonstrates the determinant role played by the individual immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the course of the disease. Thanks to the large number of published data, we are beginning to understand the logic of the human response to a virus adapted to bat immunity. RECENT FINDINGS: Impairment of types I and III interferon responses may facilitate the occurrence of severe COVID-19 with reduced antiviral activity associated to potent inflammation. The human T and B-cell germline repertoire contain the specificities able to react against SARS-CoV-2 antigens. Although inflammation disrupts the structure of germinal centers, memory T and B cells can be found in the blood of patients after mild and severe COVID 19. SUMMARY: Further studies are indispensable to better understand the human immune response to SARS-CoV-2. The diversity of the individual reaction may contribute to explain the clinical manifestation spectrum. Immunological memory can be demonstrated in patients, convalescent from mild, moderate, or severe COVID-19, but we do not know whether asymptomatic individuals have memory of the virus. Tailored vaccination protocols may be needed for individuals with previous SAS-CoV-2 infection. Twit Text FOAVip COVID-19 - pathogenesis and immunological findings across the clinical manifestation spectrum ????Curr Opin Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=33629970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33629970 #FOAvip English Wikipedia <ref>{{Cite pmid|33629970}}</ref> COVID-19 - pathogenesis and immunological findings across the clinical manifestation spectrum #MMPMID33629970 Carsetti R; Quinti I; Locatelli F Curr Opin Pulm Med 2021[May]; 27 (3): 193-198 PMID33629970show ga PURPOSE OF REVIEW: The wide spectrum of COVID-19 clinical manifestations demonstrates the determinant role played by the individual immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the course of the disease. Thanks to the large number of published data, we are beginning to understand the logic of the human response to a virus adapted to bat immunity. RECENT FINDINGS: Impairment of types I and III interferon responses may facilitate the occurrence of severe COVID-19 with reduced antiviral activity associated to potent inflammation. The human T and B-cell germline repertoire contain the specificities able to react against SARS-CoV-2 antigens. Although inflammation disrupts the structure of germinal centers, memory T and B cells can be found in the blood of patients after mild and severe COVID 19. SUMMARY: Further studies are indispensable to better understand the human immune response to SARS-CoV-2. The diversity of the individual reaction may contribute to explain the clinical manifestation spectrum. Immunological memory can be demonstrated in patients, convalescent from mild, moderate, or severe COVID-19, but we do not know whether asymptomatic individuals have memory of the virus. Tailored vaccination protocols may be needed for individuals with previous SAS-CoV-2 infection. |*COVID-19/immunology/physiopathology/prevention & control[MESH] |Asymptomatic Infections[MESH] |COVID-19 Vaccines/*pharmacology[MESH] |Humans[MESH] |Immunity/*physiology[MESH] |Immunologic Memory[MESH] |SARS-CoV-2/*immunology[MESH]COVID-19 - pathogenesis and immunological findings across the clinical(epmc).pdf DeepDyve Pubget Overpricing