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10.1007/s00395-021-00852-0 http://scihub22266oqcxt.onion/10.1007/s00395-021-00852-0 33629195!7904035!33629195     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33629195&cmd=llinks): Failed to open stream: HTTP request failed! 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Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response |pdf=|usr=}}{{33629195}} gab.com Text Does remote ischaemic conditioning reduce inflammation A focus on innate immunity and cytokine response JO: Basic Res Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=33629195 #FOAvip The benefits of remote ischaemic conditioning (RIC) have been difficult to translate to humans, when considering traditional outcome measures, such as mortality and heart failure. This paper reviews the recent literature of the anti-inflammatory effects of RIC, with a particular focus on the innate immune response and cytokine inhibition. Given the current COVID-19 pandemic, the inflammatory hypothesis of cardiac protection is an attractive target on which to re-purpose such novel therapies. A PubMed/MEDLINE search was performed on July 13th 2020, for the key terms RIC, cytokines, the innate immune system and inflammation. Data suggest that RIC attenuates inflammation in animals by immune conditioning, cytokine inhibition, cell survival and the release of anti-inflammatory exosomes. It is proposed that RIC inhibits cytokine release via a reduction in nuclear factor kappa beta (NF-kappaB)-mediated NLRP3 inflammasome production. In vivo, RIC attenuates pro-inflammatory cytokine release in myocardial/cerebral infarction and LPS models of endotoxaemia. In the latter group, cytokine inhibition is associated with a profound survival benefit. Further clinical trials should establish whether the benefits of RIC in inflammation can be observed in humans. Moreover, we must consider whether uncomplicated MI and elective surgery are the most suitable clinical conditions in which to test this hypothesis. Twit Text FOAVip Does remote ischaemic conditioning reduce inflammation A focus on innate immunity and cytokine response ????Basic Res Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=33629195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33629195 #FOAvip English Wikipedia <ref>{{Cite pmid|33629195}}</ref> Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response #MMPMID33629195 Pearce L; Davidson SM; Yellon DM Basic Res Cardiol 2021[Feb]; 116 (1): 12 PMID33629195show ga The benefits of remote ischaemic conditioning (RIC) have been difficult to translate to humans, when considering traditional outcome measures, such as mortality and heart failure. This paper reviews the recent literature of the anti-inflammatory effects of RIC, with a particular focus on the innate immune response and cytokine inhibition. Given the current COVID-19 pandemic, the inflammatory hypothesis of cardiac protection is an attractive target on which to re-purpose such novel therapies. A PubMed/MEDLINE search was performed on July 13th 2020, for the key terms RIC, cytokines, the innate immune system and inflammation. Data suggest that RIC attenuates inflammation in animals by immune conditioning, cytokine inhibition, cell survival and the release of anti-inflammatory exosomes. It is proposed that RIC inhibits cytokine release via a reduction in nuclear factor kappa beta (NF-kappaB)-mediated NLRP3 inflammasome production. In vivo, RIC attenuates pro-inflammatory cytokine release in myocardial/cerebral infarction and LPS models of endotoxaemia. In the latter group, cytokine inhibition is associated with a profound survival benefit. Further clinical trials should establish whether the benefits of RIC in inflammation can be observed in humans. Moreover, we must consider whether uncomplicated MI and elective surgery are the most suitable clinical conditions in which to test this hypothesis. |*Immunity, Innate[MESH] |*Ischemic Preconditioning, Myocardial[MESH] |Animals[MESH] |COVID-19/complications[MESH] |Cell Survival[MESH] |Cytokines/*physiology[MESH] |Extracellular Vesicles/physiology[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Inflammation/blood/*therapy[MESH]Does remote ischaemic conditioning reduce inflammation? A focus on inn(epmc).pdf DeepDyve Pubget Overpricing