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10.1155/2021/6692409

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33628349!7881736!33628349
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suck abstract from ncbi


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pmid33628349      Can+Respir+J 2021 ; 2021 (ä): 6692409
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  • A Follow-Up Study of Lung Function and Chest Computed Tomography at 6 Months after Discharge in Patients with Coronavirus Disease 2019 #MMPMID33628349
  • Wu Q; Zhong L; Li H; Guo J; Li Y; Hou X; Yang F; Xie Y; Li L; Xing Z
  • Can Respir J 2021[]; 2021 (ä): 6692409 PMID33628349show ga
  • We aimed to investigate changes in pulmonary function and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) during the recovery period. COVID-19 patients underwent symptom assessment, pulmonary function tests, and high-resolution chest CT 6 months after discharge from the hospital. Of the 54 patients enrolled, 31 and 23 were in the moderate and severe group, respectively. The main symptoms 6 months after discharge were fatigue and exertional dyspnea, experienced by 24.1% and 18.5% of patients, respectively, followed by smell and taste dysfunction (9.3%) and cough (5.6%). One patient dropped out of the pulmonary function tests. Of the remaining 54 patients, 41.5% had pulmonary dysfunction. Specifically, 7.5% presented with restrictive ventilatory dysfunction (forced vital capacity <80% of the predicted value), 18.9% presented with small airway dysfunction, and 32.1% presented with pulmonary diffusion impairment (diffusing capacity for carbon monoxide <80% of the predicted value). Of the 54 patients enrolled, six patients dropped out of the chest CT tests. Eleven of the remaining 48 patients presented with abnormal lung CT findings 6 months after discharge. Patients with residual lung lesions were more common in the severe group (52.6%) than in the moderate group (3.4%); a higher proportion of patients had involvement of both lungs (42.1% vs. 3.4%) in the severe group. The residual lung lesions were mainly ground-glass opacities (20.8%) and linear opacities (14.6%). Semiquantitative visual scoring of the CT findings revealed significantly higher scores in the left, right, and both lungs in the severe group than in the moderate group. COVID-19 patients 6 months after discharge mostly presented with fatigue and exertional dyspnea, and their pulmonary dysfunction was mostly characterized by pulmonary diffusion impairment. As revealed by chest CT, the severe group had a higher prevalence of residual lesions than the moderate group, and the residual lesions mostly manifested as ground-glass opacities and linear opacities.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/diagnostic imaging/*physiopathology[MESH]
  • |Cough/physiopathology[MESH]
  • |Dyspnea/*physiopathology[MESH]
  • |Fatigue/*physiopathology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Forced Expiratory Volume[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging/*physiopathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Olfaction Disorders/physiopathology[MESH]
  • |Peak Expiratory Flow Rate[MESH]
  • |Pulmonary Diffusing Capacity[MESH]
  • |Recovery of Function[MESH]
  • |Respiratory Function Tests[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Taste Disorders/physiopathology[MESH]
  • |Tomography, X-Ray Computed[MESH]


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