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10.1038/s41467-021-21389-9 http://scihub22266oqcxt.onion/10.1038/s41467-021-21389-9 33627662!7904795!33627662     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1260 Nephropedia Template TP {{tp|p=33627662|t=2021. Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 |pdf=|usr=}}{{33627662}} gab.com Text Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33627662 #FOAvip A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety and efficacy of novel vaccines and therapeutics. Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. Immune responses against SARS-CoV-2 are also similar in both species and equivalent to those reported in milder infections and convalescent human patients. This finding is reiterated by our transcriptional analysis of respiratory samples revealing the global response to infection. We describe a new method for lung histopathology scoring that will provide a metric to enable clearer decision making for this key endpoint. In contrast to prior publications, in which rhesus are accepted to be the preferred study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both species should be used to evaluate the safety and efficacy of interventions against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks. Twit Text FOAVip Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33627662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33627662 #FOAvip English Wikipedia <ref>{{Cite pmid|33627662}}</ref> Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 #MMPMID33627662 Salguero FJ; White AD; Slack GS; Fotheringham SA; Bewley KR; Gooch KE; Longet S; Humphries HE; Watson RJ; Hunter L; Ryan KA; Hall Y; Sibley L; Sarfas C; Allen L; Aram M; Brunt E; Brown P; Buttigieg KR; Cavell BE; Cobb R; Coombes NS; Darby A; Daykin-Pont O; Elmore MJ; Garcia-Dorival I; Gkolfinos K; Godwin KJ; Gouriet J; Halkerston R; Harris DJ; Hender T; Ho CMK; Kennard CL; Knott D; Leung S; Lucas V; Mabbutt A; Morrison AL; Nelson C; Ngabo D; Paterson J; Penn EJ; Pullan S; Taylor I; Tipton T; Thomas S; Tree JA; Turner C; Vamos E; Wand N; Wiblin NR; Charlton S; Dong X; Hallis B; Pearson G; Rayner EL; Nicholson AG; Funnell SG; Hiscox JA; Dennis MJ; Gleeson FV; Sharpe S; Carroll MW Nat Commun 2021[Feb]; 12 (1): 1260 PMID33627662show ga A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety and efficacy of novel vaccines and therapeutics. Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. Immune responses against SARS-CoV-2 are also similar in both species and equivalent to those reported in milder infections and convalescent human patients. This finding is reiterated by our transcriptional analysis of respiratory samples revealing the global response to infection. We describe a new method for lung histopathology scoring that will provide a metric to enable clearer decision making for this key endpoint. In contrast to prior publications, in which rhesus are accepted to be the preferred study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both species should be used to evaluate the safety and efficacy of interventions against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks. |Animals[MESH] |COVID-19/*immunology/*virology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Immunity, Cellular/physiology[MESH] |Interferon-gamma/metabolism[MESH] |Lung/*pathology/*virology[MESH] |Macaca fascicularis[MESH] |Macaca mulatta[MESH] |Male[MESH] |Pandemics[MESH]Comparison of rhesus and cynomolgus macaques as an infection model for(epmc).pdf DeepDyve Pubget Overpricing