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10.1186/s12879-021-05897-z

http://scihub22266oqcxt.onion/10.1186/s12879-021-05897-z
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33627079!7903394!33627079
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suck abstract from ncbi


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pmid33627079      BMC+Infect+Dis 2021 ; 21 (1): 207
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  • Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study #MMPMID33627079
  • Zhang H; Du F; Cao XJ; Feng XL; Zhang HP; Wu ZX; Wang BF; Zhang HJ; Liu R; Yang JJ; Ning B; Chen K; Huang ZP
  • BMC Infect Dis 2021[Feb]; 21 (1): 207 PMID33627079show ga
  • BACKGROUND: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China. METHODS: Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe). RESULTS: Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05). CONCLUSION: Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/blood/*complications/epidemiology[MESH]
  • |Case-Control Studies[MESH]
  • |China/epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Serum Amyloid A Protein/analysis[MESH]


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