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10.1042/BSR20204201

http://scihub22266oqcxt.onion/10.1042/BSR20204201
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33625490!7955102!33625490
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suck abstract from ncbi


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pmid33625490      Biosci+Rep 2021 ; 41 (3): ä
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  • The SARS-CoV-2 induced targeted amino acid profiling in patients at hospitalized and convalescent stage #MMPMID33625490
  • Wu J; Zhao M; Li C; Zhang Y; Wang DW
  • Biosci Rep 2021[Mar]; 41 (3): ä PMID33625490show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has induced an ongoing global health crisis. Here we utilized a combination of targeted amino acids (AAs) and clinical biochemical profiling to analyze the plasma of coronavirus disease 2019 (COVID-19) subjects at the hospitalization stage and 1-month post-infection convalescent stage, respectively, to investigate the systematic injury during COVID-19 disease progress. We found the virus-induced inflammatory status and reduced liver synthesis capacity in hospitalized patients, which manifested with increased branched-chain AAs (BCAAs), aromatic AAs (AAAs), one-carbon related metabolites, and decreased methionine. Most of these disturbances during infection recover except for the increased levels of medium-chain acylcarnitines (ACs) in the convalescent subjects, implying the existence of incomplete fatty acids oxidation during recovery periods. Our results suggested that the imbalance of the AA profiling in COVID-19 patients. The majority of disturbed AAs recovered in 1 month. The incomplete fatty acid oxidation products suggested it might take longer time for convalescent patients to get complete recovery.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Amino Acids/blood/*metabolism[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/diagnosis/epidemiology/*metabolism/*virology[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Metabolomics/methods[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*physiology[MESH]


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