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10.11604/pamj.supp.2020.35.2.23267

http://scihub22266oqcxt.onion/10.11604/pamj.supp.2020.35.2.23267
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33623561!7875730!33623561
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suck abstract from ncbi


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pmid33623561      Pan+Afr+Med+J 2020 ; 35 (Suppl 2): 36
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  • Immunity, parasites, genetics and sex hormones: contributors to mild inflammatory responses in COVID-19? #MMPMID33623561
  • Munjita SM; Samutela M; Ndashe K; Munsaka SM
  • Pan Afr Med J 2020[]; 35 (Suppl 2): 36 PMID33623561show ga
  • The Coronavirus disease 2019 (COVID-19) pandemic has killed over two hundred thousand people by end of April, 2020. America and Europe top in deaths from COVID-19 whereas the numbers are lower in Africa for unclear reasons. Emerging evidence suggests the role of hyperactive immune responses characterised by high pro-inflammatory cytokines in severe cases of COVID-19 and deaths. In this perspective, we explore the possible factors that may contribute to mild inflammatory responses in some cases of COVID-19 by focusing on immune education, parasites, sex hormones and chronic diseases, as well as genetic tolerance. To build our perspective, evidence is also extracted from wild rodents due to their multi-tasking immune responses as a result of constant exposure to pathogens.
  • |Animals[MESH]
  • |COVID-19/*immunology/physiopathology[MESH]
  • |Cytokines/*immunology[MESH]
  • |Gonadal Steroid Hormones/metabolism[MESH]
  • |Humans[MESH]
  • |Immunity/immunology[MESH]
  • |Inflammation/immunology/*virology[MESH]
  • |Parasitic Diseases/immunology/parasitology[MESH]
  • |Rodentia[MESH]


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