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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pan+Afr+Med+J 2020 ; 35 (Suppl 2): 36 Nephropedia Template TP
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Immunity, parasites, genetics and sex hormones: contributors to mild inflammatory responses in COVID-19? #MMPMID33623561
Munjita SM; Samutela M; Ndashe K; Munsaka SM
Pan Afr Med J 2020[]; 35 (Suppl 2): 36 PMID33623561show ga
The Coronavirus disease 2019 (COVID-19) pandemic has killed over two hundred thousand people by end of April, 2020. America and Europe top in deaths from COVID-19 whereas the numbers are lower in Africa for unclear reasons. Emerging evidence suggests the role of hyperactive immune responses characterised by high pro-inflammatory cytokines in severe cases of COVID-19 and deaths. In this perspective, we explore the possible factors that may contribute to mild inflammatory responses in some cases of COVID-19 by focusing on immune education, parasites, sex hormones and chronic diseases, as well as genetic tolerance. To build our perspective, evidence is also extracted from wild rodents due to their multi-tasking immune responses as a result of constant exposure to pathogens.