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10.1126/sciimmunol.abg6916 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abg6916 33622975!8128290!33622975     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (56): ä Nephropedia Template TP {{tp|p=33622975|t=2021. Prolonged evolution of the human B cell response to SARS-CoV-2 infection |pdf=|usr=}}{{33622975}} gab.com Text Prolonged evolution of the human B cell response to SARS-CoV-2 infection JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33622975 #FOAvip A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months. Serum neutralizing antibody (nAb) responses waned rapidly but spike (S)-specific IgG(+) memory B cells (MBCs) remained stable or increased over time. Analysis of 1,213 monoclonal antibodies (mAbs) isolated from S-specific MBCs revealed a primarily de novo response that displayed increased somatic hypermutation, binding affinity, and neutralization potency over time, providing evidence for prolonged antibody affinity maturation. B cell immunodominance hierarchies were similar across donor repertoires and remained relatively stable as the immune response progressed. Cross-reactive B cell populations, likely re-called from prior endemic beta-coronavirus exposures, comprised a small but stable fraction of the repertoires and did not contribute to the neutralizing response. The neutralizing antibody response was dominated by public clonotypes that displayed significantly reduced activity against SARS-CoV-2 variants emerging in Brazil and South Africa that harbor mutations at positions 501, 484 and 417 in the S protein. Overall, the results provide insight into the dynamics, durability, and functional properties of the human B cell response to SARS-CoV-2 infection and have implications for the design of immunogens that preferentially stimulate protective B cell responses. Twit Text FOAVip Prolonged evolution of the human B cell response to SARS-CoV-2 infection ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33622975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33622975 #FOAvip English Wikipedia <ref>{{Cite pmid|33622975}}</ref> Prolonged evolution of the human B cell response to SARS-CoV-2 infection #MMPMID33622975 Sakharkar M; Rappazzo CG; Wieland-Alter WF; Hsieh CL; Wrapp D; Esterman ES; Kaku CI; Wec AZ; Geoghegan JC; McLellan JS; Connor RI; Wright PF; Walker LM Sci Immunol 2021[Feb]; 6 (56): ä PMID33622975show ga A comprehensive understanding of the kinetics and evolution of the human B cell response to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and therapies. Here, we longitudinally profiled this response in mild and severe COVID-19 patients over a period of five months. Serum neutralizing antibody (nAb) responses waned rapidly but spike (S)-specific IgG(+) memory B cells (MBCs) remained stable or increased over time. Analysis of 1,213 monoclonal antibodies (mAbs) isolated from S-specific MBCs revealed a primarily de novo response that displayed increased somatic hypermutation, binding affinity, and neutralization potency over time, providing evidence for prolonged antibody affinity maturation. B cell immunodominance hierarchies were similar across donor repertoires and remained relatively stable as the immune response progressed. Cross-reactive B cell populations, likely re-called from prior endemic beta-coronavirus exposures, comprised a small but stable fraction of the repertoires and did not contribute to the neutralizing response. The neutralizing antibody response was dominated by public clonotypes that displayed significantly reduced activity against SARS-CoV-2 variants emerging in Brazil and South Africa that harbor mutations at positions 501, 484 and 417 in the S protein. Overall, the results provide insight into the dynamics, durability, and functional properties of the human B cell response to SARS-CoV-2 infection and have implications for the design of immunogens that preferentially stimulate protective B cell responses. |Adult[MESH] |Aged[MESH] |Antibodies, Monoclonal/immunology[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |B-Lymphocytes/*immunology[MESH] |Binding Sites[MESH] |COVID-19/*immunology/virology[MESH] |Cohort Studies[MESH] |Cross Reactions[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH]Prolonged evolution of the human B cell response to SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing