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10.1016/j.mycmed.2021.101122

http://scihub22266oqcxt.onion/10.1016/j.mycmed.2021.101122
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33621792!7884920!33621792
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suck abstract from ncbi


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pmid33621792      J+Mycol+Med 2021 ; 31 (2): 101122
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  • Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort #MMPMID33621792
  • Versyck M; Zarrougui W; Lambiotte F; Elbeki N; Saint-Leger P
  • J Mycol Med 2021[Jun]; 31 (2): 101122 PMID33621792show ga
  • INTRODUCTION: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular for invasive pulmonary aspergillosis. The main objective here is to define the prevalence of invasive pulmonary aspergillosis (IPA) in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS). MATERIAL AND METHODS: We conducted a large monocentric retrospective study investigating all the ventilated COVID-19 patients with ARDS hospitalized at Valenciennes' general hospital, France, between March 15, 2020 and April 30, 2020. In the center a systematic IPA screening strategy was carried out for all ARDS patients, with weekly tests of serum galactomannan and beta-D-glucan. Bronchoalveolar lavage with culture and chest CT scan were performed when the serum assays were positives. RESULTS: A total of 54 patients were studied. Their median age was 65 years, and 37 of the patients (71%) were male. Two patients had chronic immunosuppression and among all the patients, only 2 non-immunocompromised presented a putative IPA during their stay. CONCLUSION: The prevalence of IPA in this cohort of COVID-19 patients (3.7%) is not higher than what is described in the other ARDS populations in the literature. These results are however different from the previous publications on COVID-19 patients and must therefore be confirmed by larger and multicentric studies.
  • |*Critical Illness[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*complications[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Galactose/analogs & derivatives[MESH]
  • |Hospitals, General/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Invasive Pulmonary Aspergillosis/*complications/diagnosis[MESH]
  • |Male[MESH]
  • |Mannans/blood[MESH]
  • |Middle Aged[MESH]
  • |Opportunistic Infections/*complications[MESH]
  • |Respiration, Artificial[MESH]
  • |Respiratory Distress Syndrome/*etiology/therapy[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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