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10.1016/j.cell.2021.01.037 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.01.037 33621484!7843029!33621484     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (5): 1171-1187.e20 Nephropedia Template TP {{tp|p=33621484|t=2021. Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity |pdf=|usr=}}{{33621484}} gab.com Text Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33621484 #FOAvip SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding affinity to the hACE2 receptor, and N439K viruses have similar in vitro replication fitness and cause infections with similar clinical outcomes as compared to wild type. We show the N439K mutation confers resistance against several neutralizing monoclonal antibodies, including one authorized for emergency use by the US Food and Drug Administration (FDA), and reduces the activity of some polyclonal sera from persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics. Twit Text FOAVip Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33621484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33621484 #FOAvip English Wikipedia <ref>{{Cite pmid|33621484}}</ref> Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity #MMPMID33621484 Thomson EC; Rosen LE; Shepherd JG; Spreafico R; da Silva Filipe A; Wojcechowskyj JA; Davis C; Piccoli L; Pascall DJ; Dillen J; Lytras S; Czudnochowski N; Shah R; Meury M; Jesudason N; De Marco A; Li K; Bassi J; O'Toole A; Pinto D; Colquhoun RM; Culap K; Jackson B; Zatta F; Rambaut A; Jaconi S; Sreenu VB; Nix J; Zhang I; Jarrett RF; Glass WG; Beltramello M; Nomikou K; Pizzuto M; Tong L; Cameroni E; Croll TI; Johnson N; Di Iulio J; Wickenhagen A; Ceschi A; Harbison AM; Mair D; Ferrari P; Smollett K; Sallusto F; Carmichael S; Garzoni C; Nichols J; Galli M; Hughes J; Riva A; Ho A; Schiuma M; Semple MG; Openshaw PJM; Fadda E; Baillie JK; Chodera JD; Rihn SJ; Lycett SJ; Virgin HW; Telenti A; Corti D; Robertson DL; Snell G Cell 2021[Mar]; 184 (5): 1171-1187.e20 PMID33621484show ga SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding affinity to the hACE2 receptor, and N439K viruses have similar in vitro replication fitness and cause infections with similar clinical outcomes as compared to wild type. We show the N439K mutation confers resistance against several neutralizing monoclonal antibodies, including one authorized for emergency use by the US Food and Drug Administration (FDA), and reduces the activity of some polyclonal sera from persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics. |*Genetic Fitness[MESH] |*Immune Evasion[MESH] |Angiotensin-Converting Enzyme 2/chemistry[MESH] |Antibodies, Neutralizing/genetics/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*immunology/virology[MESH] |Humans[MESH] |Mutation[MESH] |Phylogeny[MESH] |SARS-CoV-2/chemistry/*genetics/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics[MESH]Circulating SARS-CoV-2 spike N439K variants maintain fitness while eva(epmc).pdf DeepDyve Pubget Overpricing