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10.1172/jci.insight.146242 http://scihub22266oqcxt.onion/10.1172/jci.insight.146242 33621211!8026190!33621211     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (6): ä Nephropedia Template TP {{tp|p=33621211|t=2021. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2 |pdf=|usr=}}{{33621211}} gab.com Text Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33621211 #FOAvip Comorbid medical illnesses, such as obesity and diabetes, are associated with more severe COVID-19, hospitalization, and death. However, the role of the immune system in mediating these clinical outcomes has not been determined. We used multiparameter flow cytometry and systems serology to comprehensively profile the functions of T cells and antibodies targeting spike, nucleocapsid, and envelope proteins in a convalescent cohort of COVID-19 subjects who were either hospitalized (n = 20) or not hospitalized (n = 40). To avoid confounding, subjects were matched by age, sex, ethnicity, and date of symptom onset. Surprisingly, we found that the magnitude and functional breadth of virus-specific CD4+ T cell and antibody responses were consistently higher among hospitalized subjects, particularly those with medical comorbidities. However, an integrated analysis identified more coordination between polyfunctional CD4+ T cells and antibodies targeting the S1 domain of spike among subjects who were not hospitalized. These data reveal a functionally diverse and coordinated response between T cells and antibodies targeting SARS-CoV-2, which is reduced in the presence of comorbid illnesses that are known risk factors for severe COVID-19. Twit Text FOAVip Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33621211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33621211 #FOAvip English Wikipedia <ref>{{Cite pmid|33621211}}</ref> Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2 #MMPMID33621211 Yu KK; Fischinger S; Smith MT; Atyeo C; Cizmeci D; Wolf CR; Layton ED; Logue JK; Aguilar MS; Shuey K; Loos C; Yu J; Franko N; Choi RY; Wald A; Barouch DH; Koelle DM; Lauffenburger D; Chu HY; Alter G; Seshadri C JCI Insight 2021[Mar]; 6 (6): ä PMID33621211show ga Comorbid medical illnesses, such as obesity and diabetes, are associated with more severe COVID-19, hospitalization, and death. However, the role of the immune system in mediating these clinical outcomes has not been determined. We used multiparameter flow cytometry and systems serology to comprehensively profile the functions of T cells and antibodies targeting spike, nucleocapsid, and envelope proteins in a convalescent cohort of COVID-19 subjects who were either hospitalized (n = 20) or not hospitalized (n = 40). To avoid confounding, subjects were matched by age, sex, ethnicity, and date of symptom onset. Surprisingly, we found that the magnitude and functional breadth of virus-specific CD4+ T cell and antibody responses were consistently higher among hospitalized subjects, particularly those with medical comorbidities. However, an integrated analysis identified more coordination between polyfunctional CD4+ T cells and antibodies targeting the S1 domain of spike among subjects who were not hospitalized. These data reveal a functionally diverse and coordinated response between T cells and antibodies targeting SARS-CoV-2, which is reduced in the presence of comorbid illnesses that are known risk factors for severe COVID-19. |*Hospitalization[MESH] |*Spike Glycoprotein, Coronavirus[MESH] |*Virion[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/metabolism/physiology[MESH] |Antibodies, Viral/metabolism/*physiology[MESH] |CD4-Positive T-Lymphocytes/metabolism/*physiology[MESH] |COVID-19/epidemiology/immunology/*virology[MESH] |Cardiovascular Diseases/epidemiology/immunology[MESH] |Comorbidity[MESH] |Diabetes Mellitus/epidemiology/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Male[MESH] |Middle Aged[MESH] |Nucleocapsid[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH] |Viral Envelope[MESH] |Viral Proteins[MESH]Comorbid illnesses are associated with altered adaptive immune respons(epmc).pdf DeepDyve Pubget Overpricing