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10.1093/bib/bbab043

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33620066!7929326!33620066
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suck abstract from ncbi


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pmid33620066      Brief+Bioinform 2021 ; 22 (2): 1466-1475
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  • Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19 #MMPMID33620066
  • Fang S; Zhang L; Liu Y; Xu W; Wu W; Huang Z; Wang X; Liu H; Sun Y; Zhang R; Peng B; Liu X; Sun X; Yu J; Chan FKL; Ng SC; Wong SH; Wang MHT; Gin T; Joynt GM; Hui DSC; Feng T; Wu WKK; Chan MTV; Zou X; Xia J
  • Brief Bioinform 2021[Mar]; 22 (2): 1466-1475 PMID33620066show ga
  • Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, causing significant mortality. There is a mechanistic relationship between intracellular coronavirus replication and deregulated autophagosome-lysosome system. We performed transcriptome analysis of peripheral blood mononuclear cells (PBMCs) from COVID-19 patients and identified the aberrant upregulation of genes in the lysosome pathway. We further determined the capability of two circulating markers, namely microtubule-associated proteins 1A/1B light chain 3B (LC3B) and (p62/SQSTM1) p62, both of which depend on lysosome for degradation, in predicting the emergence of moderate-to-severe disease in COVID-19 patients requiring hospitalization for supplemental oxygen therapy. Logistic regression analyses showed that LC3B was associated with moderate-to-severe COVID-19, independent of age, sex and clinical risk score. A decrease in LC3B concentration <5.5 ng/ml increased the risk of oxygen and ventilatory requirement (adjusted odds ratio: 4.6; 95% CI: 1.1-22.0; P = 0.04). Serum concentrations of p62 in the moderate-to-severe group were significantly lower in patients aged 50 or below. In conclusion, lysosome function is deregulated in PBMCs isolated from COVID-19 patients, and the related biomarker LC3B may serve as a novel tool for stratifying patients with moderate-to-severe COVID-19 from those with asymptomatic or mild disease. COVID-19 patients with a decrease in LC3B concentration <5.5 ng/ml will require early hospital admission for supplemental oxygen therapy and other respiratory support.
  • |Adult[MESH]
  • |Autophagy[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/blood/*virology[MESH]
  • |Cell Cycle[MESH]
  • |Cholesterol/metabolism[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Leukocytes, Mononuclear/*metabolism[MESH]
  • |Lysosomes/*metabolism[MESH]
  • |Male[MESH]
  • |Microtubule-Associated Proteins/*blood[MESH]
  • |Middle Aged[MESH]
  • |RNA-Binding Proteins/blood[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Retrospective Studies[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]


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