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10.1038/s41467-021-21463-2 http://scihub22266oqcxt.onion/10.1038/s41467-021-21463-2 33619281!7900119!33619281     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1221 Nephropedia Template TP {{tp|p=33619281|t=2021. Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients |pdf=|usr=}}{{33619281}} gab.com Text Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33619281 #FOAvip Hospitalized COVID-19 patients often present with a large spectrum of clinical symptoms. There is a critical need to better understand the immune responses to SARS-CoV-2 that lead to either resolution or exacerbation of the clinical disease. Here, we examine longitudinal plasma samples from hospitalized COVID-19 patients with differential clinical outcome. We perform immune-repertoire analysis including cytokine, hACE2-receptor inhibition, neutralization titers, antibody epitope repertoire, antibody kinetics, antibody isotype and antibody affinity maturation against the SARS-CoV-2 prefusion spike protein. Fatal cases demonstrate high plasma levels of IL-6, IL-8, TNFalpha, and MCP-1, and sustained high percentage of IgA-binding antibodies to prefusion spike compared with non-ICU survivors. Disease resolution in non-ICU and ICU patients associates with antibody binding to the receptor binding motif and fusion peptide, and antibody affinity maturation to SARS-CoV-2 prefusion spike protein. Here, we provide insight into the immune parameters associated with clinical disease severity and disease-resolution outcome in hospitalized patients that could inform development of vaccine/therapeutics against COVID-19. Twit Text FOAVip Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33619281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33619281 #FOAvip English Wikipedia <ref>{{Cite pmid|33619281}}</ref> Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients #MMPMID33619281 Tang J; Ravichandran S; Lee Y; Grubbs G; Coyle EM; Klenow L; Genser H; Golding H; Khurana S Nat Commun 2021[Feb]; 12 (1): 1221 PMID33619281show ga Hospitalized COVID-19 patients often present with a large spectrum of clinical symptoms. There is a critical need to better understand the immune responses to SARS-CoV-2 that lead to either resolution or exacerbation of the clinical disease. Here, we examine longitudinal plasma samples from hospitalized COVID-19 patients with differential clinical outcome. We perform immune-repertoire analysis including cytokine, hACE2-receptor inhibition, neutralization titers, antibody epitope repertoire, antibody kinetics, antibody isotype and antibody affinity maturation against the SARS-CoV-2 prefusion spike protein. Fatal cases demonstrate high plasma levels of IL-6, IL-8, TNFalpha, and MCP-1, and sustained high percentage of IgA-binding antibodies to prefusion spike compared with non-ICU survivors. Disease resolution in non-ICU and ICU patients associates with antibody binding to the receptor binding motif and fusion peptide, and antibody affinity maturation to SARS-CoV-2 prefusion spike protein. Here, we provide insight into the immune parameters associated with clinical disease severity and disease-resolution outcome in hospitalized patients that could inform development of vaccine/therapeutics against COVID-19. |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/immunology/metabolism[MESH] |Antibodies, Neutralizing/blood/*immunology[MESH] |Antibodies, Viral/blood/*immunology[MESH] |Antibody Affinity/*immunology[MESH] |COVID-19/blood/*immunology/virology[MESH] |Cohort Studies[MESH] |Cytokines/blood/immunology/metabolism[MESH] |Epitopes/immunology[MESH] |Female[MESH] |Hospitalization/statistics & numerical data[MESH] |Humans[MESH] |Immunoglobulin A/blood/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests[MESH] |SARS-CoV-2/*immunology/metabolism/physiology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Antibody affinity maturation and plasma IgA associate with clinical ou(epmc).pdf DeepDyve Pubget Overpricing